International observational study of nutritional support in mechanically ventilated patients following burn injury

Adam Czapran, William Headdon, Adam M. Deane, Kylie Lange, Marianne J. Chapman, Daren K. Heyland

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Abstract

Introduction It has been proposed that nutritional therapy in critically ill patients after major burn reduces mortality. However, the actual practice of nutrient delivery, and the effect on outcome, has not been described. Study objectives To evaluate international practices related to nutritional support and outcomes in mechanically ventilated patients with burn injury. Methods Data from the International Nutrition Surveys (2007-2011) for patients with a primary diagnosis of burn were extracted and analysed. Results Eighty-eight of 90 patients (aged 16-84 years) received enteral nutrition. The median time for initiation of enteral feeding was 17 h [range 0-65]. Fifty patients (57%) had interruptions to nutrient delivery, most often these interruptions were fasting for operative procedures. There were substantive energy and protein deficits [943 (654) kcal/day and 49 (41) g/day, respectively; mean (SD)]. Nineteen (21%) patients died within 60 days of admission, and the energy and protein deficits were greater in those that died compared with survivors [died vs. survived, energy: 1251 (742) vs. 861 (607) kcal/d; p = 0.02; and protein 67(42) vs. 44(39) g/d; p = 0.03]. Energy and protein deficits were associated with increased mortality with the greater the deficit, the stronger the association with death (odds ratio for death: energy deficit/100 kcal 1.10 (1.01, 1.19); p = 0.028 and protein/10 g 1.16 (1.01, 1.33); p = 0.037). Results were similar and remained significant after adjusting for severity of illness. Conclusions Mechanically ventilated patients following burn develop substantial energy and protein deficits, with lesser deficits observed in survivors.

Original languageEnglish
Pages (from-to)510-518
Number of pages9
JournalBurns : Journal of the International Society for Burn Injuries
Volume41
Issue number3
DOIs
Publication statusPublished - May 2015
Externally publishedYes

Keywords

  • Burn
  • Critical illness
  • Deficit
  • Energy
  • ICU
  • Intensive care
  • International nutrition survey
  • Nutrition
  • Protein

Cite this

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title = "International observational study of nutritional support in mechanically ventilated patients following burn injury",
abstract = "Introduction It has been proposed that nutritional therapy in critically ill patients after major burn reduces mortality. However, the actual practice of nutrient delivery, and the effect on outcome, has not been described. Study objectives To evaluate international practices related to nutritional support and outcomes in mechanically ventilated patients with burn injury. Methods Data from the International Nutrition Surveys (2007-2011) for patients with a primary diagnosis of burn were extracted and analysed. Results Eighty-eight of 90 patients (aged 16-84 years) received enteral nutrition. The median time for initiation of enteral feeding was 17 h [range 0-65]. Fifty patients (57{\%}) had interruptions to nutrient delivery, most often these interruptions were fasting for operative procedures. There were substantive energy and protein deficits [943 (654) kcal/day and 49 (41) g/day, respectively; mean (SD)]. Nineteen (21{\%}) patients died within 60 days of admission, and the energy and protein deficits were greater in those that died compared with survivors [died vs. survived, energy: 1251 (742) vs. 861 (607) kcal/d; p = 0.02; and protein 67(42) vs. 44(39) g/d; p = 0.03]. Energy and protein deficits were associated with increased mortality with the greater the deficit, the stronger the association with death (odds ratio for death: energy deficit/100 kcal 1.10 (1.01, 1.19); p = 0.028 and protein/10 g 1.16 (1.01, 1.33); p = 0.037). Results were similar and remained significant after adjusting for severity of illness. Conclusions Mechanically ventilated patients following burn develop substantial energy and protein deficits, with lesser deficits observed in survivors.",
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International observational study of nutritional support in mechanically ventilated patients following burn injury. / Czapran, Adam; Headdon, William; Deane, Adam M.; Lange, Kylie; Chapman, Marianne J.; Heyland, Daren K.

In: Burns : Journal of the International Society for Burn Injuries, Vol. 41, No. 3, 05.2015, p. 510-518.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - International observational study of nutritional support in mechanically ventilated patients following burn injury

AU - Czapran, Adam

AU - Headdon, William

AU - Deane, Adam M.

AU - Lange, Kylie

AU - Chapman, Marianne J.

AU - Heyland, Daren K.

PY - 2015/5

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N2 - Introduction It has been proposed that nutritional therapy in critically ill patients after major burn reduces mortality. However, the actual practice of nutrient delivery, and the effect on outcome, has not been described. Study objectives To evaluate international practices related to nutritional support and outcomes in mechanically ventilated patients with burn injury. Methods Data from the International Nutrition Surveys (2007-2011) for patients with a primary diagnosis of burn were extracted and analysed. Results Eighty-eight of 90 patients (aged 16-84 years) received enteral nutrition. The median time for initiation of enteral feeding was 17 h [range 0-65]. Fifty patients (57%) had interruptions to nutrient delivery, most often these interruptions were fasting for operative procedures. There were substantive energy and protein deficits [943 (654) kcal/day and 49 (41) g/day, respectively; mean (SD)]. Nineteen (21%) patients died within 60 days of admission, and the energy and protein deficits were greater in those that died compared with survivors [died vs. survived, energy: 1251 (742) vs. 861 (607) kcal/d; p = 0.02; and protein 67(42) vs. 44(39) g/d; p = 0.03]. Energy and protein deficits were associated with increased mortality with the greater the deficit, the stronger the association with death (odds ratio for death: energy deficit/100 kcal 1.10 (1.01, 1.19); p = 0.028 and protein/10 g 1.16 (1.01, 1.33); p = 0.037). Results were similar and remained significant after adjusting for severity of illness. Conclusions Mechanically ventilated patients following burn develop substantial energy and protein deficits, with lesser deficits observed in survivors.

AB - Introduction It has been proposed that nutritional therapy in critically ill patients after major burn reduces mortality. However, the actual practice of nutrient delivery, and the effect on outcome, has not been described. Study objectives To evaluate international practices related to nutritional support and outcomes in mechanically ventilated patients with burn injury. Methods Data from the International Nutrition Surveys (2007-2011) for patients with a primary diagnosis of burn were extracted and analysed. Results Eighty-eight of 90 patients (aged 16-84 years) received enteral nutrition. The median time for initiation of enteral feeding was 17 h [range 0-65]. Fifty patients (57%) had interruptions to nutrient delivery, most often these interruptions were fasting for operative procedures. There were substantive energy and protein deficits [943 (654) kcal/day and 49 (41) g/day, respectively; mean (SD)]. Nineteen (21%) patients died within 60 days of admission, and the energy and protein deficits were greater in those that died compared with survivors [died vs. survived, energy: 1251 (742) vs. 861 (607) kcal/d; p = 0.02; and protein 67(42) vs. 44(39) g/d; p = 0.03]. Energy and protein deficits were associated with increased mortality with the greater the deficit, the stronger the association with death (odds ratio for death: energy deficit/100 kcal 1.10 (1.01, 1.19); p = 0.028 and protein/10 g 1.16 (1.01, 1.33); p = 0.037). Results were similar and remained significant after adjusting for severity of illness. Conclusions Mechanically ventilated patients following burn develop substantial energy and protein deficits, with lesser deficits observed in survivors.

KW - Burn

KW - Critical illness

KW - Deficit

KW - Energy

KW - ICU

KW - Intensive care

KW - International nutrition survey

KW - Nutrition

KW - Protein

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