Interleukin-6 Interacts with Sleep Apnea Severity when Predicting Incident Alzheimer's Disease Dementia

Andrée Ann Baril; Alexa S. Beiser; Susan Redline; Emer R. McGrath; Daniel J. Gottlieb; Hugo Aparicio; Sudha Seshadri; Jayandra J. Himali; Matthew P. Pase

doi:10.3233/JAD-200545

Interleukin-6 Interacts with Sleep Apnea Severity when Predicting Incident Alzheimer's Disease Dementia

Andrée Ann Baril, Alexa S. Beiser, Susan Redline, Emer R. McGrath, Daniel J. Gottlieb, Hugo Aparicio, Sudha Seshadri, Jayandra J. Himali, Matthew P. Pase

Psychology

Research output: Contribution to journal › Article › Research › peer-review

5 Citations (Scopus)

Abstract

Because of their roles as potential risk factors, we evaluated whether obstructive sleep apnea (OSA) severity interacts with interleukin-6 (IL-6) in predicting incident dementia of the Alzheimer's type (DAT). In 269 dementia-free participants, IL-6 and the apnea-hypopnea index (AHI) were measured at baseline and incident DAT was surveilled for up to 22.8 years. Cox models revealed a significant interaction: In the lowest IL-6 quartile only, a higher AHI was associated with an elevated risk of DAT. The association between OSA severity and incident DAT might be especially apparent in the absence of inflammation or absence of potential benefits from IL-6.

Original language	English
Pages (from-to)	1451-1457
Number of pages	7
Journal	Journal of Alzheimer's Disease
Volume	79
Issue number	4
DOIs	https://doi.org/10.3233/JAD-200545
Publication status	Published - 16 Feb 2021

Keywords

Alzheimer's disease
dementia
inflammation
interleukin-6
sleep apnea
sleep disorders
sleep-disordered breathing

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3233/JAD-200545

Cite this

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title = "Interleukin-6 Interacts with Sleep Apnea Severity when Predicting Incident Alzheimer's Disease Dementia",

abstract = "Because of their roles as potential risk factors, we evaluated whether obstructive sleep apnea (OSA) severity interacts with interleukin-6 (IL-6) in predicting incident dementia of the Alzheimer's type (DAT). In 269 dementia-free participants, IL-6 and the apnea-hypopnea index (AHI) were measured at baseline and incident DAT was surveilled for up to 22.8 years. Cox models revealed a significant interaction: In the lowest IL-6 quartile only, a higher AHI was associated with an elevated risk of DAT. The association between OSA severity and incident DAT might be especially apparent in the absence of inflammation or absence of potential benefits from IL-6.",

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T1 - Interleukin-6 Interacts with Sleep Apnea Severity when Predicting Incident Alzheimer's Disease Dementia

AU - Baril, Andrée Ann

AU - Beiser, Alexa S.

AU - Redline, Susan

AU - McGrath, Emer R.

AU - Gottlieb, Daniel J.

AU - Aparicio, Hugo

AU - Seshadri, Sudha

AU - Himali, Jayandra J.

AU - Pase, Matthew P.

PY - 2021/2/16

Y1 - 2021/2/16

N2 - Because of their roles as potential risk factors, we evaluated whether obstructive sleep apnea (OSA) severity interacts with interleukin-6 (IL-6) in predicting incident dementia of the Alzheimer's type (DAT). In 269 dementia-free participants, IL-6 and the apnea-hypopnea index (AHI) were measured at baseline and incident DAT was surveilled for up to 22.8 years. Cox models revealed a significant interaction: In the lowest IL-6 quartile only, a higher AHI was associated with an elevated risk of DAT. The association between OSA severity and incident DAT might be especially apparent in the absence of inflammation or absence of potential benefits from IL-6.

AB - Because of their roles as potential risk factors, we evaluated whether obstructive sleep apnea (OSA) severity interacts with interleukin-6 (IL-6) in predicting incident dementia of the Alzheimer's type (DAT). In 269 dementia-free participants, IL-6 and the apnea-hypopnea index (AHI) were measured at baseline and incident DAT was surveilled for up to 22.8 years. Cox models revealed a significant interaction: In the lowest IL-6 quartile only, a higher AHI was associated with an elevated risk of DAT. The association between OSA severity and incident DAT might be especially apparent in the absence of inflammation or absence of potential benefits from IL-6.

KW - Alzheimer's disease

KW - dementia

KW - inflammation

KW - interleukin-6

KW - sleep apnea

KW - sleep disorders

KW - sleep-disordered breathing

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IS - 4

ER -

Interleukin-6 Interacts with Sleep Apnea Severity when Predicting Incident Alzheimer's Disease Dementia

Abstract

Keywords

UN SDGs

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