Interleukin-6 Interacts with Sleep Apnea Severity when Predicting Incident Alzheimer's Disease Dementia

Andrée Ann Baril, Alexa S. Beiser, Susan Redline, Emer R. McGrath, Daniel J. Gottlieb, Hugo Aparicio, Sudha Seshadri, Jayandra J. Himali, Matthew P. Pase

Research output: Contribution to journalArticleResearchpeer-review


Because of their roles as potential risk factors, we evaluated whether obstructive sleep apnea (OSA) severity interacts with interleukin-6 (IL-6) in predicting incident dementia of the Alzheimer's type (DAT). In 269 dementia-free participants, IL-6 and the apnea-hypopnea index (AHI) were measured at baseline and incident DAT was surveilled for up to 22.8 years. Cox models revealed a significant interaction: In the lowest IL-6 quartile only, a higher AHI was associated with an elevated risk of DAT. The association between OSA severity and incident DAT might be especially apparent in the absence of inflammation or absence of potential benefits from IL-6.

Original languageEnglish
Pages (from-to)1451-1457
Number of pages7
JournalJournal of Alzheimer's Disease
Issue number4
Publication statusPublished - 16 Feb 2021


  • Alzheimer's disease
  • dementia
  • inflammation
  • interleukin-6
  • sleep apnea
  • sleep disorders
  • sleep-disordered breathing

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