Interleukin-6 (IL-6) response to a simulated night-shift schedule is modulated by brain-derived neurotrophic factor (BDNF) genotype

Brieann C. Satterfield; Marina I. Savenkova; Ilia N. Karatsoreos; Melinda L. Jackson; Gregory Belenky; Hans P.A. Van Dongen

doi:10.1080/07420528.2020.1803901

Interleukin-6 (IL-6) response to a simulated night-shift schedule is modulated by brain-derived neurotrophic factor (BDNF) genotype

Brieann C. Satterfield, Marina I. Savenkova, Ilia N. Karatsoreos, Melinda L. Jackson, Gregory Belenky, Hans P.A. Van Dongen

Psychology

Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)

Abstract

The BDNF gene contains a polymorphism (Val66Met) that influences sleep and may be associated with more flexible adaptation to circadian misalignment. Fifteen adult men (10 Val/Val homozygotes, 5 Val/Met heterozygotes) participated in a laboratory study involving two 5 d cycles of simulated night shifts. Circulating interleukin-6 (IL-6) was measured from plasma, sleep was recorded polysomnographically, and performance was measured using a psychomotor vigilance test. Compared to Val/Val homozygotes, heterozygotes exhibited a blunted IL-6 temporal (diurnal) pattern, less daytime sleep restriction, and less nighttime performance impairment after the first simulated night-shift cycle. These observations suggest that heterozygotes experienced more flexible circadian adaptation.

Original language	English
Pages (from-to)	1452-1456
Number of pages	5
Journal	Chronobiology International
Volume	37
Issue number	10
DOIs	https://doi.org/10.1080/07420528.2020.1803901
Publication status	Published - 2 Oct 2020

Keywords

Circadian adaptation
circadian misalignment
IL-6 diurnal pattern
immune response
laboratory study
physiological stressor response
shift work
single nucleotide polymorphism
sleep loss

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10.1080/07420528.2020.1803901

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title = "Interleukin-6 (IL-6) response to a simulated night-shift schedule is modulated by brain-derived neurotrophic factor (BDNF) genotype",

abstract = "The BDNF gene contains a polymorphism (Val66Met) that influences sleep and may be associated with more flexible adaptation to circadian misalignment. Fifteen adult men (10 Val/Val homozygotes, 5 Val/Met heterozygotes) participated in a laboratory study involving two 5 d cycles of simulated night shifts. Circulating interleukin-6 (IL-6) was measured from plasma, sleep was recorded polysomnographically, and performance was measured using a psychomotor vigilance test. Compared to Val/Val homozygotes, heterozygotes exhibited a blunted IL-6 temporal (diurnal) pattern, less daytime sleep restriction, and less nighttime performance impairment after the first simulated night-shift cycle. These observations suggest that heterozygotes experienced more flexible circadian adaptation.",

keywords = "Circadian adaptation, circadian misalignment, IL-6 diurnal pattern, immune response, laboratory study, physiological stressor response, shift work, single nucleotide polymorphism, sleep loss",

author = "Satterfield, \{Brieann C.\} and Savenkova, \{Marina I.\} and Karatsoreos, \{Ilia N.\} and Jackson, \{Melinda L.\} and Gregory Belenky and \{Van Dongen\}, \{Hans P.A.\}",

year = "2020",

month = oct,

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doi = "10.1080/07420528.2020.1803901",

language = "English",

volume = "37",

pages = "1452--1456",

journal = "Chronobiology International",

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T1 - Interleukin-6 (IL-6) response to a simulated night-shift schedule is modulated by brain-derived neurotrophic factor (BDNF) genotype

AU - Satterfield, Brieann C.

AU - Savenkova, Marina I.

AU - Karatsoreos, Ilia N.

AU - Jackson, Melinda L.

AU - Belenky, Gregory

AU - Van Dongen, Hans P.A.

PY - 2020/10/2

Y1 - 2020/10/2

N2 - The BDNF gene contains a polymorphism (Val66Met) that influences sleep and may be associated with more flexible adaptation to circadian misalignment. Fifteen adult men (10 Val/Val homozygotes, 5 Val/Met heterozygotes) participated in a laboratory study involving two 5 d cycles of simulated night shifts. Circulating interleukin-6 (IL-6) was measured from plasma, sleep was recorded polysomnographically, and performance was measured using a psychomotor vigilance test. Compared to Val/Val homozygotes, heterozygotes exhibited a blunted IL-6 temporal (diurnal) pattern, less daytime sleep restriction, and less nighttime performance impairment after the first simulated night-shift cycle. These observations suggest that heterozygotes experienced more flexible circadian adaptation.

AB - The BDNF gene contains a polymorphism (Val66Met) that influences sleep and may be associated with more flexible adaptation to circadian misalignment. Fifteen adult men (10 Val/Val homozygotes, 5 Val/Met heterozygotes) participated in a laboratory study involving two 5 d cycles of simulated night shifts. Circulating interleukin-6 (IL-6) was measured from plasma, sleep was recorded polysomnographically, and performance was measured using a psychomotor vigilance test. Compared to Val/Val homozygotes, heterozygotes exhibited a blunted IL-6 temporal (diurnal) pattern, less daytime sleep restriction, and less nighttime performance impairment after the first simulated night-shift cycle. These observations suggest that heterozygotes experienced more flexible circadian adaptation.

KW - Circadian adaptation

KW - circadian misalignment

KW - IL-6 diurnal pattern

KW - immune response

KW - laboratory study

KW - physiological stressor response

KW - shift work

KW - single nucleotide polymorphism

KW - sleep loss

UR - https://www.scopus.com/pages/publications/85089702307

U2 - 10.1080/07420528.2020.1803901

DO - 10.1080/07420528.2020.1803901

M3 - Article

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AN - SCOPUS:85089702307

SN - 0742-0528

VL - 37

SP - 1452

EP - 1456

JO - Chronobiology International

JF - Chronobiology International

IS - 10

ER -

Interleukin-6 (IL-6) response to a simulated night-shift schedule is modulated by brain-derived neurotrophic factor (BDNF) genotype

Abstract

Keywords

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