Interleukin-6 (IL-6) response to a simulated night-shift schedule is modulated by brain-derived neurotrophic factor (BDNF) genotype

Brieann C. Satterfield, Marina I. Savenkova, Ilia N. Karatsoreos, Melinda L. Jackson, Gregory Belenky, Hans P.A. Van Dongen

Research output: Contribution to journalArticleResearchpeer-review


The BDNF gene contains a polymorphism (Val66Met) that influences sleep and may be associated with more flexible adaptation to circadian misalignment. Fifteen adult men (10 Val/Val homozygotes, 5 Val/Met heterozygotes) participated in a laboratory study involving two 5 d cycles of simulated night shifts. Circulating interleukin-6 (IL-6) was measured from plasma, sleep was recorded polysomnographically, and performance was measured using a psychomotor vigilance test. Compared to Val/Val homozygotes, heterozygotes exhibited a blunted IL-6 temporal (diurnal) pattern, less daytime sleep restriction, and less nighttime performance impairment after the first simulated night-shift cycle. These observations suggest that heterozygotes experienced more flexible circadian adaptation.

Original languageEnglish
Number of pages5
JournalChronobiology International
Publication statusAccepted/In press - 20 Aug 2020


  • Circadian adaptation
  • circadian misalignment
  • IL-6 diurnal pattern
  • immune response
  • laboratory study
  • physiological stressor response
  • shift work
  • single nucleotide polymorphism
  • sleep loss

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