TY - JOUR
T1 - Interleukin-6 (IL-6) response to a simulated night-shift schedule is modulated by brain-derived neurotrophic factor (BDNF) genotype
AU - Satterfield, Brieann C.
AU - Savenkova, Marina I.
AU - Karatsoreos, Ilia N.
AU - Jackson, Melinda L.
AU - Belenky, Gregory
AU - Van Dongen, Hans P.A.
PY - 2020/10/2
Y1 - 2020/10/2
N2 - The BDNF gene contains a polymorphism (Val66Met) that influences sleep and may be associated with more flexible adaptation to circadian misalignment. Fifteen adult men (10 Val/Val homozygotes, 5 Val/Met heterozygotes) participated in a laboratory study involving two 5 d cycles of simulated night shifts. Circulating interleukin-6 (IL-6) was measured from plasma, sleep was recorded polysomnographically, and performance was measured using a psychomotor vigilance test. Compared to Val/Val homozygotes, heterozygotes exhibited a blunted IL-6 temporal (diurnal) pattern, less daytime sleep restriction, and less nighttime performance impairment after the first simulated night-shift cycle. These observations suggest that heterozygotes experienced more flexible circadian adaptation.
AB - The BDNF gene contains a polymorphism (Val66Met) that influences sleep and may be associated with more flexible adaptation to circadian misalignment. Fifteen adult men (10 Val/Val homozygotes, 5 Val/Met heterozygotes) participated in a laboratory study involving two 5 d cycles of simulated night shifts. Circulating interleukin-6 (IL-6) was measured from plasma, sleep was recorded polysomnographically, and performance was measured using a psychomotor vigilance test. Compared to Val/Val homozygotes, heterozygotes exhibited a blunted IL-6 temporal (diurnal) pattern, less daytime sleep restriction, and less nighttime performance impairment after the first simulated night-shift cycle. These observations suggest that heterozygotes experienced more flexible circadian adaptation.
KW - Circadian adaptation
KW - circadian misalignment
KW - IL-6 diurnal pattern
KW - immune response
KW - laboratory study
KW - physiological stressor response
KW - shift work
KW - single nucleotide polymorphism
KW - sleep loss
UR - http://www.scopus.com/inward/record.url?scp=85089702307&partnerID=8YFLogxK
U2 - 10.1080/07420528.2020.1803901
DO - 10.1080/07420528.2020.1803901
M3 - Article
C2 - 32819178
AN - SCOPUS:85089702307
SN - 0742-0528
VL - 37
SP - 1452
EP - 1456
JO - Chronobiology International
JF - Chronobiology International
IS - 10
ER -