Interleukin-38 exerts antiinflammatory functions and is associated with disease activity in systemic lupus erythematosus

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Abstract

Knowledge of interleukin-38 (IL-38), formerly IL-1 family member 10, is sparse, but Il1f10 polymorphisms are associated with inflammatory diseases, and recombinant IL-38 inhibits inflammatory responses similar to those reported in the context of systemic lupus erythematosus (SLE). We undertook this study to explore the function of endogenous IL-38 in human peripheral blood mononuclear cells (PBMCs) as well as its abundance in serum in a well-characterized cohort of SLE patients. METHODS: Serum IL-38 and IL-10 levels were quantified by enzyme-linked immunosorbent assay in 142 SLE patients at /=4) than in those with inactive disease (SLEDAI-2K score of
Original languageEnglish
Pages (from-to)3219 - 3225
Number of pages7
JournalArthritis and Rheumatology
Volume67
Issue number12
DOIs
Publication statusPublished - 2015

Cite this

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title = "Interleukin-38 exerts antiinflammatory functions and is associated with disease activity in systemic lupus erythematosus",
abstract = "Knowledge of interleukin-38 (IL-38), formerly IL-1 family member 10, is sparse, but Il1f10 polymorphisms are associated with inflammatory diseases, and recombinant IL-38 inhibits inflammatory responses similar to those reported in the context of systemic lupus erythematosus (SLE). We undertook this study to explore the function of endogenous IL-38 in human peripheral blood mononuclear cells (PBMCs) as well as its abundance in serum in a well-characterized cohort of SLE patients. METHODS: Serum IL-38 and IL-10 levels were quantified by enzyme-linked immunosorbent assay in 142 SLE patients at /=4) than in those with inactive disease (SLEDAI-2K score of",
author = "Ina Rudloff and Jack Godsell and Nold-Petry, {Claudia Annelie} and James Harris and Alberta Hoi and Morand, {Eric Francis} and Nold, {Marcel Friedrich}",
year = "2015",
doi = "10.1002/art.39328",
language = "English",
volume = "67",
pages = "3219 -- 3225",
journal = "Arthritis and Rheumatology",
issn = "2326-5191",
publisher = "Wiley-Blackwell",
number = "12",

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TY - JOUR

T1 - Interleukin-38 exerts antiinflammatory functions and is associated with disease activity in systemic lupus erythematosus

AU - Rudloff, Ina

AU - Godsell, Jack

AU - Nold-Petry, Claudia Annelie

AU - Harris, James

AU - Hoi, Alberta

AU - Morand, Eric Francis

AU - Nold, Marcel Friedrich

PY - 2015

Y1 - 2015

N2 - Knowledge of interleukin-38 (IL-38), formerly IL-1 family member 10, is sparse, but Il1f10 polymorphisms are associated with inflammatory diseases, and recombinant IL-38 inhibits inflammatory responses similar to those reported in the context of systemic lupus erythematosus (SLE). We undertook this study to explore the function of endogenous IL-38 in human peripheral blood mononuclear cells (PBMCs) as well as its abundance in serum in a well-characterized cohort of SLE patients. METHODS: Serum IL-38 and IL-10 levels were quantified by enzyme-linked immunosorbent assay in 142 SLE patients at /=4) than in those with inactive disease (SLEDAI-2K score of

AB - Knowledge of interleukin-38 (IL-38), formerly IL-1 family member 10, is sparse, but Il1f10 polymorphisms are associated with inflammatory diseases, and recombinant IL-38 inhibits inflammatory responses similar to those reported in the context of systemic lupus erythematosus (SLE). We undertook this study to explore the function of endogenous IL-38 in human peripheral blood mononuclear cells (PBMCs) as well as its abundance in serum in a well-characterized cohort of SLE patients. METHODS: Serum IL-38 and IL-10 levels were quantified by enzyme-linked immunosorbent assay in 142 SLE patients at /=4) than in those with inactive disease (SLEDAI-2K score of

UR - http://onlinelibrary.wiley.com/doi/10.1002/art.39328/epdf

U2 - 10.1002/art.39328

DO - 10.1002/art.39328

M3 - Article

VL - 67

SP - 3219

EP - 3225

JO - Arthritis and Rheumatology

JF - Arthritis and Rheumatology

SN - 2326-5191

IS - 12

ER -