Interleukin-38 exerts antiinflammatory functions and is associated with disease activity in systemic lupus erythematosus

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Abstract

Knowledge of interleukin-38 (IL-38), formerly IL-1 family member 10, is sparse, but Il1f10 polymorphisms are associated with inflammatory diseases, and recombinant IL-38 inhibits inflammatory responses similar to those reported in the context of systemic lupus erythematosus (SLE). We undertook this study to explore the function of endogenous IL-38 in human peripheral blood mononuclear cells (PBMCs) as well as its abundance in serum in a well-characterized cohort of SLE patients. METHODS: Serum IL-38 and IL-10 levels were quantified by enzyme-linked immunosorbent assay in 142 SLE patients at /=4) than in those with inactive disease (SLEDAI-2K score of
Original languageEnglish
Pages (from-to)3219 - 3225
Number of pages7
JournalArthritis & Rheumatology
Volume67
Issue number12
DOIs
Publication statusPublished - 2015

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