Interleukin-28B rs12979860 C allele: protective against advanced fibrosis in chronic hepatitis C genotype 1 infection

Matthew T Kitson, Jacob George, Gregory J Dore, Reynold Leung, Peter Button, Geoffrey McCaughan, Darrell Crawford, William Sievert, Martin D Weltman, Wendy Cheng, Stuart Keith Roberts

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Abstract

Background and Aim: While genetic polymorphisms upstream of the interleukin-28B (IL28B) gene are associated with necroinflammatory activity grade in chronic hepatitis C virus genotype 1 (HCV-1) infection, any association with fibrosis is less definitive. Pretreatment liver biopsies in a cohort of treatment-naive patients with HCV-1 were analyzed to evaluate associations between liver histology, and the rs12979860 and rs8099917 IL28B single nucleotide polymorphisms. Methods: Two hundred sixty-six patients with HCV-1 infection and pretreatment liver biopsy were tested for the rs12979860 and rs8099917 single nucleotide polymorphisms. Predictors of advanced fibrosis (METAVIR F3/4) and high activity grade (A2/3) were identified using multivariable logistic regression analysis. Results: Forty-four patients (16.5 ) had advanced fibrosis and 141 patients (53.0 ) high activity grade. Prevalence of rs12979860 IL28B genotype was: CC 45.7 , CT 42.7 , and TT 11.6 . Prevalence of advanced fibrosis was lower in those with IL28B CC genotype compared with those without (11.0 vs 21.3 ; P=0.03), with an increasing number of T alleles associated with a higher frequency of advanced fibrosis: CC 11.0 , CT 18.0 , TT 33.3 (P=0.01). Predictors of advanced fibrosis on multivariate analysis were platelet count (odds ratio [OR] 0.98, 95 confidence interval [CI] 0.97-0.99; P
Original languageEnglish
Pages (from-to)1458 - 1462
Number of pages5
JournalJournal of Gastroenterology and Hepatology
Volume29
Issue number7
DOIs
Publication statusPublished - 2014

Cite this

Kitson, Matthew T ; George, Jacob ; Dore, Gregory J ; Leung, Reynold ; Button, Peter ; McCaughan, Geoffrey ; Crawford, Darrell ; Sievert, William ; Weltman, Martin D ; Cheng, Wendy ; Roberts, Stuart Keith. / Interleukin-28B rs12979860 C allele: protective against advanced fibrosis in chronic hepatitis C genotype 1 infection. In: Journal of Gastroenterology and Hepatology. 2014 ; Vol. 29, No. 7. pp. 1458 - 1462.
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abstract = "Background and Aim: While genetic polymorphisms upstream of the interleukin-28B (IL28B) gene are associated with necroinflammatory activity grade in chronic hepatitis C virus genotype 1 (HCV-1) infection, any association with fibrosis is less definitive. Pretreatment liver biopsies in a cohort of treatment-naive patients with HCV-1 were analyzed to evaluate associations between liver histology, and the rs12979860 and rs8099917 IL28B single nucleotide polymorphisms. Methods: Two hundred sixty-six patients with HCV-1 infection and pretreatment liver biopsy were tested for the rs12979860 and rs8099917 single nucleotide polymorphisms. Predictors of advanced fibrosis (METAVIR F3/4) and high activity grade (A2/3) were identified using multivariable logistic regression analysis. Results: Forty-four patients (16.5 ) had advanced fibrosis and 141 patients (53.0 ) high activity grade. Prevalence of rs12979860 IL28B genotype was: CC 45.7 , CT 42.7 , and TT 11.6 . Prevalence of advanced fibrosis was lower in those with IL28B CC genotype compared with those without (11.0 vs 21.3 ; P=0.03), with an increasing number of T alleles associated with a higher frequency of advanced fibrosis: CC 11.0 , CT 18.0 , TT 33.3 (P=0.01). Predictors of advanced fibrosis on multivariate analysis were platelet count (odds ratio [OR] 0.98, 95 confidence interval [CI] 0.97-0.99; P",
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Interleukin-28B rs12979860 C allele: protective against advanced fibrosis in chronic hepatitis C genotype 1 infection. / Kitson, Matthew T; George, Jacob; Dore, Gregory J; Leung, Reynold; Button, Peter; McCaughan, Geoffrey; Crawford, Darrell; Sievert, William; Weltman, Martin D; Cheng, Wendy; Roberts, Stuart Keith.

In: Journal of Gastroenterology and Hepatology, Vol. 29, No. 7, 2014, p. 1458 - 1462.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Interleukin-28B rs12979860 C allele: protective against advanced fibrosis in chronic hepatitis C genotype 1 infection

AU - Kitson, Matthew T

AU - George, Jacob

AU - Dore, Gregory J

AU - Leung, Reynold

AU - Button, Peter

AU - McCaughan, Geoffrey

AU - Crawford, Darrell

AU - Sievert, William

AU - Weltman, Martin D

AU - Cheng, Wendy

AU - Roberts, Stuart Keith

PY - 2014

Y1 - 2014

N2 - Background and Aim: While genetic polymorphisms upstream of the interleukin-28B (IL28B) gene are associated with necroinflammatory activity grade in chronic hepatitis C virus genotype 1 (HCV-1) infection, any association with fibrosis is less definitive. Pretreatment liver biopsies in a cohort of treatment-naive patients with HCV-1 were analyzed to evaluate associations between liver histology, and the rs12979860 and rs8099917 IL28B single nucleotide polymorphisms. Methods: Two hundred sixty-six patients with HCV-1 infection and pretreatment liver biopsy were tested for the rs12979860 and rs8099917 single nucleotide polymorphisms. Predictors of advanced fibrosis (METAVIR F3/4) and high activity grade (A2/3) were identified using multivariable logistic regression analysis. Results: Forty-four patients (16.5 ) had advanced fibrosis and 141 patients (53.0 ) high activity grade. Prevalence of rs12979860 IL28B genotype was: CC 45.7 , CT 42.7 , and TT 11.6 . Prevalence of advanced fibrosis was lower in those with IL28B CC genotype compared with those without (11.0 vs 21.3 ; P=0.03), with an increasing number of T alleles associated with a higher frequency of advanced fibrosis: CC 11.0 , CT 18.0 , TT 33.3 (P=0.01). Predictors of advanced fibrosis on multivariate analysis were platelet count (odds ratio [OR] 0.98, 95 confidence interval [CI] 0.97-0.99; P

AB - Background and Aim: While genetic polymorphisms upstream of the interleukin-28B (IL28B) gene are associated with necroinflammatory activity grade in chronic hepatitis C virus genotype 1 (HCV-1) infection, any association with fibrosis is less definitive. Pretreatment liver biopsies in a cohort of treatment-naive patients with HCV-1 were analyzed to evaluate associations between liver histology, and the rs12979860 and rs8099917 IL28B single nucleotide polymorphisms. Methods: Two hundred sixty-six patients with HCV-1 infection and pretreatment liver biopsy were tested for the rs12979860 and rs8099917 single nucleotide polymorphisms. Predictors of advanced fibrosis (METAVIR F3/4) and high activity grade (A2/3) were identified using multivariable logistic regression analysis. Results: Forty-four patients (16.5 ) had advanced fibrosis and 141 patients (53.0 ) high activity grade. Prevalence of rs12979860 IL28B genotype was: CC 45.7 , CT 42.7 , and TT 11.6 . Prevalence of advanced fibrosis was lower in those with IL28B CC genotype compared with those without (11.0 vs 21.3 ; P=0.03), with an increasing number of T alleles associated with a higher frequency of advanced fibrosis: CC 11.0 , CT 18.0 , TT 33.3 (P=0.01). Predictors of advanced fibrosis on multivariate analysis were platelet count (odds ratio [OR] 0.98, 95 confidence interval [CI] 0.97-0.99; P

UR - http://onlinelibrary.wiley.com/doi/10.1111/jgh.12544/pdf

U2 - 10.1111/jgh.12544

DO - 10.1111/jgh.12544

M3 - Article

VL - 29

SP - 1458

EP - 1462

JO - Journal of Gastroenterology and Hepatology

JF - Journal of Gastroenterology and Hepatology

SN - 0815-9319

IS - 7

ER -