Interleukin-18: Perspectives on the newest interleukin

Matthew T. Gillespie, Nicole J. Horwood

Research output: Contribution to journalShort SurveyResearchpeer-review

81 Citations (Scopus)


Just over two years ago the newest member of the interleukin family of cytokines, IL-18, was molecularly cloned. IL-18 was originally identified as a result of its ability to induce interferon gamma production, however with the advent of its cloning and the production of recombinant protein a number of other biological actions have since been identified. Recently the receptor for IL-18 was also characterised. Due to the structural and biological properties shared between IL-18 and IL-1 and their respective receptors, questions relating to IL-18 activities are being answered at a rapid pace. This article addresses the biology of IL-18 in both disease and non-disease states.

Original languageEnglish
Pages (from-to)109-116
Number of pages8
JournalCytokine and Growth Factor Reviews
Issue number2
Publication statusPublished - 1 May 1998
Externally publishedYes


  • Cytokines
  • IGI
  • IL-18
  • Interferon gamma
  • T cells

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