Interleukin-12 regulates chemokine gene expression during the early immune response to Leishmania major

Colby Zaph; Phillip Scott

doi:10.1128/IAI.71.3.1587-1589.2003

Interleukin-12 regulates chemokine gene expression during the early immune response to Leishmania major

Colby Zaph, Phillip Scott

Research output: Contribution to journal › Article › Research › peer-review

34 Citations (Scopus)

Abstract

Following infection with Leishmania major, the chemokines XCL1, CXCL10, and CCL2 were preferentially expressed in draining lymph nodes of resistant mice. Neutralization of interleukin 12 (IL-12) or gamma interferon in resistant mice resulted in decreased chemokine expression, while administration of IL-12 to susceptible mice resulted in an increase in the level of chemokine gene expression.

Original language	English
Pages (from-to)	1587-1589
Number of pages	3
Journal	Infection and Immunity
Volume	71
Issue number	3
DOIs	https://doi.org/10.1128/IAI.71.3.1587-1589.2003
Publication status	Published - 1 Mar 2003
Externally published	Yes

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10.1128/IAI.71.3.1587-1589.2003

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title = "Interleukin-12 regulates chemokine gene expression during the early immune response to Leishmania major",

abstract = "Following infection with Leishmania major, the chemokines XCL1, CXCL10, and CCL2 were preferentially expressed in draining lymph nodes of resistant mice. Neutralization of interleukin 12 (IL-12) or gamma interferon in resistant mice resulted in decreased chemokine expression, while administration of IL-12 to susceptible mice resulted in an increase in the level of chemokine gene expression.",

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AB - Following infection with Leishmania major, the chemokines XCL1, CXCL10, and CCL2 were preferentially expressed in draining lymph nodes of resistant mice. Neutralization of interleukin 12 (IL-12) or gamma interferon in resistant mice resulted in decreased chemokine expression, while administration of IL-12 to susceptible mice resulted in an increase in the level of chemokine gene expression.

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Interleukin-12 regulates chemokine gene expression during the early immune response to Leishmania major

Abstract

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