Interleukin-12 regulates chemokine gene expression during the early immune response to Leishmania major

Colby Zaph, Phillip Scott

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Abstract

Following infection with Leishmania major, the chemokines XCL1, CXCL10, and CCL2 were preferentially expressed in draining lymph nodes of resistant mice. Neutralization of interleukin 12 (IL-12) or gamma interferon in resistant mice resulted in decreased chemokine expression, while administration of IL-12 to susceptible mice resulted in an increase in the level of chemokine gene expression.

Original languageEnglish
Pages (from-to)1587-1589
Number of pages3
JournalInfection and Immunity
Volume71
Issue number3
DOIs
Publication statusPublished - 1 Mar 2003
Externally publishedYes

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