Interleukin-12 regulates chemokine gene expression during the early immune response to Leishmania major

Colby Zaph, Phillip Scott

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)


Following infection with Leishmania major, the chemokines XCL1, CXCL10, and CCL2 were preferentially expressed in draining lymph nodes of resistant mice. Neutralization of interleukin 12 (IL-12) or gamma interferon in resistant mice resulted in decreased chemokine expression, while administration of IL-12 to susceptible mice resulted in an increase in the level of chemokine gene expression.

Original languageEnglish
Pages (from-to)1587-1589
Number of pages3
JournalInfection and Immunity
Issue number3
Publication statusPublished - 1 Mar 2003
Externally publishedYes

Cite this