Interleukin 11: Similar or opposite roles in female reproduction and reproductive cancer?

Amy Winship, Ellen Menkhorst, Michelle Van Sinderen, Evdokia Dimitriadis

Research output: Contribution to journalReview ArticleResearchpeer-review

8 Citations (Scopus)

Abstract

During placental development and carcinogenesis, cell invasion and migration are critical events in establishing a self-supporting vascular supply. Interleukin (IL)-11 is a pleiotropic cytokine that affects the invasive and migratory capabilities of trophoblast cells that form the placenta during pregnancy, as well as various malignant cell types. The endometrium is the site of embryo implantation during pregnancy; conversely, endometrial carcinoma is the most common gynaecological malignancy. Here, we review what is known about the role of IL-11 in trophoblast function and ingynaecological malignancies, focusing primarily on the context of the uterine environment.
Original languageEnglish
Pages (from-to)395-405
Number of pages11
JournalReproduction, Fertility and Development
Volume28
Issue number4
DOIs
Publication statusPublished - 2016

Keywords

  • endometrium
  • placenta
  • pregnancy
  • trophoblast

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