Interleukin 11 is upregulated in preeclampsia and leads to inflammation and preeclampsia features in mice

Research output: Contribution to journalReview ArticleOtherpeer-review

Abstract

Preeclampsia is a dangerous pregnancy complication, which is often associated with fetal growth restriction and can have serious life-long effects for both mother and baby. While the establishment of the placenta in the first trimester is the sentinel event in the development of preeclampsia little is known of the critical mechanisms of placentation that lead to the syndrome. Locally produced inflammatory cytokines are thought to play a role in the development of preeclampsia. This review summarizes the evidence that interleukin 11 is dysregulated in preeclampsia and contributes to the initiation of preeclampsia via effects on placentation. It discusses the benefits and drawbacks of targeting IL11 as a novel treatment option for preeclampsia.

Original languageEnglish
Pages (from-to)32-38
Number of pages7
JournalJournal of Reproductive Immunology
Volume125
DOIs
Publication statusPublished - 1 Feb 2018

Keywords

  • Inflammation
  • Interleukin 11
  • Intrauterine growth restriction
  • Placenta
  • Preeclampsia
  • Trophoblast
  • Uterine-natural killer cells

Cite this

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title = "Interleukin 11 is upregulated in preeclampsia and leads to inflammation and preeclampsia features in mice",
abstract = "Preeclampsia is a dangerous pregnancy complication, which is often associated with fetal growth restriction and can have serious life-long effects for both mother and baby. While the establishment of the placenta in the first trimester is the sentinel event in the development of preeclampsia little is known of the critical mechanisms of placentation that lead to the syndrome. Locally produced inflammatory cytokines are thought to play a role in the development of preeclampsia. This review summarizes the evidence that interleukin 11 is dysregulated in preeclampsia and contributes to the initiation of preeclampsia via effects on placentation. It discusses the benefits and drawbacks of targeting IL11 as a novel treatment option for preeclampsia.",
keywords = "Inflammation, Interleukin 11, Intrauterine growth restriction, Placenta, Preeclampsia, Trophoblast, Uterine-natural killer cells",
author = "Amy Winship and Eva Dimitriadis",
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Interleukin 11 is upregulated in preeclampsia and leads to inflammation and preeclampsia features in mice. / Winship, Amy; Dimitriadis, Eva.

In: Journal of Reproductive Immunology, Vol. 125, 01.02.2018, p. 32-38.

Research output: Contribution to journalReview ArticleOtherpeer-review

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