Projects per year
Abstract
Decidual inflammation and inflammasome activation contribute to the pathogenesis of preterm birth (PTB). Interleukin-(IL)11 exerts complex regulatory effects on inflammation and IL-11 protein is elevated in PTB decidua. We aimed to determine a functional role for IL-11 in parturition or PTB. IL-11 administration during middle-late gestation pregnancy induced preterm birth in 87.5% of mice versus saline controls. Litters from IL-11-treated mothers had reduced offspring weight and numbers of live pups. IL-11 up-regulated decidual gene expression of key components of the inflammasome including IL-1β, Caspase-1 and ASC. This is the first report of a causal role for IL-11 in PTB in vivo.
Original language | English |
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Pages (from-to) | 99-101 |
Number of pages | 3 |
Journal | Placenta |
Volume | 50 |
DOIs | |
Publication status | Published - Feb 2017 |
Keywords
- Cytokines
- Decidua
- Inflammasome
- Pregnancy
Projects
- 3 Finished
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Critical regulators of endometrial receptivity
Dimitriadis, E., Gantier, M., Menkhorst, E. & Rombauts, L.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/16 → 31/10/18
Project: Research
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Critical Regulators of Embryo Implantation
National Health and Medical Research Council (NHMRC) (Australia)
1/01/12 → 31/12/16
Project: Research