Interleukin-11 induces preterm birth and modulates decidual inflammasome gene expression in mice

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Decidual inflammation and inflammasome activation contribute to the pathogenesis of preterm birth (PTB). Interleukin-(IL)11 exerts complex regulatory effects on inflammation and IL-11 protein is elevated in PTB decidua. We aimed to determine a functional role for IL-11 in parturition or PTB. IL-11 administration during middle-late gestation pregnancy induced preterm birth in 87.5% of mice versus saline controls. Litters from IL-11-treated mothers had reduced offspring weight and numbers of live pups. IL-11 up-regulated decidual gene expression of key components of the inflammasome including IL-1β, Caspase-1 and ASC. This is the first report of a causal role for IL-11 in PTB in vivo.

Original languageEnglish
Pages (from-to)99-101
Number of pages3
JournalPlacenta
Volume50
DOIs
Publication statusPublished - Feb 2017

Keywords

  • Cytokines
  • Decidua
  • Inflammasome
  • Pregnancy

Cite this

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title = "Interleukin-11 induces preterm birth and modulates decidual inflammasome gene expression in mice",
abstract = "Decidual inflammation and inflammasome activation contribute to the pathogenesis of preterm birth (PTB). Interleukin-(IL)11 exerts complex regulatory effects on inflammation and IL-11 protein is elevated in PTB decidua. We aimed to determine a functional role for IL-11 in parturition or PTB. IL-11 administration during middle-late gestation pregnancy induced preterm birth in 87.5{\%} of mice versus saline controls. Litters from IL-11-treated mothers had reduced offspring weight and numbers of live pups. IL-11 up-regulated decidual gene expression of key components of the inflammasome including IL-1β, Caspase-1 and ASC. This is the first report of a causal role for IL-11 in PTB in vivo.",
keywords = "Cytokines, Decidua, Inflammasome, Pregnancy",
author = "Amy Winship and Evdokia Dimitriadis",
year = "2017",
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language = "English",
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}

Interleukin-11 induces preterm birth and modulates decidual inflammasome gene expression in mice. / Winship, Amy; Dimitriadis, Evdokia.

In: Placenta, Vol. 50, 02.2017, p. 99-101.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Dimitriadis, Evdokia

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AB - Decidual inflammation and inflammasome activation contribute to the pathogenesis of preterm birth (PTB). Interleukin-(IL)11 exerts complex regulatory effects on inflammation and IL-11 protein is elevated in PTB decidua. We aimed to determine a functional role for IL-11 in parturition or PTB. IL-11 administration during middle-late gestation pregnancy induced preterm birth in 87.5% of mice versus saline controls. Litters from IL-11-treated mothers had reduced offspring weight and numbers of live pups. IL-11 up-regulated decidual gene expression of key components of the inflammasome including IL-1β, Caspase-1 and ASC. This is the first report of a causal role for IL-11 in PTB in vivo.

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