Interleukin 10-mediated immunosuppression by a variant CD4 T cell epitope of Plasmodium falciparum

Magdalena Plebanski; Katie L. Flanagan; Edwin A M Lee; William H H Reece; Keith Hart; Colin Gelder; Geraldine Gillespie; Margaret Pinder; Adrian V S Hill

doi:10.1016/S1074-7613(00)80064-3

Interleukin 10-mediated immunosuppression by a variant CD4 T cell epitope of Plasmodium falciparum

Magdalena Plebanski
, Katie L. Flanagan
, Edwin A M Lee
, William H H Reece
, Keith Hart
, Colin Gelder
, Geraldine Gillespie
, Margaret Pinder
, Adrian V S Hill

Research output: Contribution to journal › Article › Research › peer-review

114 Citations (Scopus)

Abstract

The immunodominant CD4 T cell epitope region, Th2R, of the circumsporozoite protein of Plasmodium falciparum is highly polymorphic. Such variation might be utilized by the parasite to escape from or interfere with CD4 T cell effector functions. Here, we show that costimulation with naturally occurring altered peptide ligands (APL) can induce a rapid change from IFNγ production to the immunosuppressive mediator interleukin 10 (IL- 10). This mechanism may contribute to the low levels of T cell responses observed to this pathogen in malaria-endemic areas.

Original language	English
Pages (from-to)	651-660
Number of pages	10
Journal	Immunity
Volume	10
Issue number	6
DOIs	https://doi.org/10.1016/S1074-7613(00)80064-3
Publication status	Published - Jun 1999
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1016/S1074-7613(00)80064-3

Cite this

@article{bf58216e81a948419e2adb87c59ce2af,

title = "Interleukin 10-mediated immunosuppression by a variant CD4 T cell epitope of Plasmodium falciparum",

abstract = "The immunodominant CD4 T cell epitope region, Th2R, of the circumsporozoite protein of Plasmodium falciparum is highly polymorphic. Such variation might be utilized by the parasite to escape from or interfere with CD4 T cell effector functions. Here, we show that costimulation with naturally occurring altered peptide ligands (APL) can induce a rapid change from IFNγ production to the immunosuppressive mediator interleukin 10 (IL- 10). This mechanism may contribute to the low levels of T cell responses observed to this pathogen in malaria-endemic areas.",

author = "Magdalena Plebanski and Flanagan, \{Katie L.\} and Lee, \{Edwin A M\} and Reece, \{William H H\} and Keith Hart and Colin Gelder and Geraldine Gillespie and Margaret Pinder and Hill, \{Adrian V S\}",

year = "1999",

month = jun,

doi = "10.1016/S1074-7613(00)80064-3",

language = "English",

volume = "10",

pages = "651--660",

journal = "Immunity",

issn = "1074-7613",

publisher = "Elsevier",

number = "6",

}

TY - JOUR

T1 - Interleukin 10-mediated immunosuppression by a variant CD4 T cell epitope of Plasmodium falciparum

AU - Plebanski, Magdalena

AU - Flanagan, Katie L.

AU - Lee, Edwin A M

AU - Reece, William H H

AU - Hart, Keith

AU - Gelder, Colin

AU - Gillespie, Geraldine

AU - Pinder, Margaret

AU - Hill, Adrian V S

PY - 1999/6

Y1 - 1999/6

N2 - The immunodominant CD4 T cell epitope region, Th2R, of the circumsporozoite protein of Plasmodium falciparum is highly polymorphic. Such variation might be utilized by the parasite to escape from or interfere with CD4 T cell effector functions. Here, we show that costimulation with naturally occurring altered peptide ligands (APL) can induce a rapid change from IFNγ production to the immunosuppressive mediator interleukin 10 (IL- 10). This mechanism may contribute to the low levels of T cell responses observed to this pathogen in malaria-endemic areas.

AB - The immunodominant CD4 T cell epitope region, Th2R, of the circumsporozoite protein of Plasmodium falciparum is highly polymorphic. Such variation might be utilized by the parasite to escape from or interfere with CD4 T cell effector functions. Here, we show that costimulation with naturally occurring altered peptide ligands (APL) can induce a rapid change from IFNγ production to the immunosuppressive mediator interleukin 10 (IL- 10). This mechanism may contribute to the low levels of T cell responses observed to this pathogen in malaria-endemic areas.

UR - https://www.scopus.com/pages/publications/0033152407

U2 - 10.1016/S1074-7613(00)80064-3

DO - 10.1016/S1074-7613(00)80064-3

M3 - Article

C2 - 10403640

AN - SCOPUS:0033152407

SN - 1074-7613

VL - 10

SP - 651

EP - 660

JO - Immunity

JF - Immunity

IS - 6

ER -

Interleukin 10-mediated immunosuppression by a variant CD4 T cell epitope of Plasmodium falciparum

Abstract

UN SDGs

Access to Document

Other files and links

Cite this