Interleukin 10-mediated immunosuppression by a variant CD4 T cell epitope of Plasmodium falciparum

Magdalena Plebanski; Katie L. Flanagan; Edwin A M Lee; William H H Reece; Keith Hart; Colin Gelder; Geraldine Gillespie; Margaret Pinder; Adrian V S Hill

doi:10.1016/S1074-7613(00)80064-3

Interleukin 10-mediated immunosuppression by a variant CD4 T cell epitope of Plasmodium falciparum

Magdalena Plebanski, Katie L. Flanagan, Edwin A M Lee, William H H Reece, Keith Hart, Colin Gelder, Geraldine Gillespie, Margaret Pinder, Adrian V S Hill

Research output: Contribution to journal › Article › Research › peer-review

114 Citations (Scopus)

Abstract

The immunodominant CD4 T cell epitope region, Th2R, of the circumsporozoite protein of Plasmodium falciparum is highly polymorphic. Such variation might be utilized by the parasite to escape from or interfere with CD4 T cell effector functions. Here, we show that costimulation with naturally occurring altered peptide ligands (APL) can induce a rapid change from IFNγ production to the immunosuppressive mediator interleukin 10 (IL- 10). This mechanism may contribute to the low levels of T cell responses observed to this pathogen in malaria-endemic areas.

Original language	English
Pages (from-to)	651-660
Number of pages	10
Journal	Immunity
Volume	10
Issue number	6
DOIs	https://doi.org/10.1016/S1074-7613(00)80064-3
Publication status	Published - Jun 1999
Externally published	Yes

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10.1016/S1074-7613(00)80064-3

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title = "Interleukin 10-mediated immunosuppression by a variant CD4 T cell epitope of Plasmodium falciparum",

abstract = "The immunodominant CD4 T cell epitope region, Th2R, of the circumsporozoite protein of Plasmodium falciparum is highly polymorphic. Such variation might be utilized by the parasite to escape from or interfere with CD4 T cell effector functions. Here, we show that costimulation with naturally occurring altered peptide ligands (APL) can induce a rapid change from IFNγ production to the immunosuppressive mediator interleukin 10 (IL- 10). This mechanism may contribute to the low levels of T cell responses observed to this pathogen in malaria-endemic areas.",

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AU - Plebanski, Magdalena

AU - Flanagan, Katie L.

AU - Lee, Edwin A M

AU - Reece, William H H

AU - Hart, Keith

AU - Gelder, Colin

AU - Gillespie, Geraldine

AU - Pinder, Margaret

AU - Hill, Adrian V S

PY - 1999/6

Y1 - 1999/6

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AB - The immunodominant CD4 T cell epitope region, Th2R, of the circumsporozoite protein of Plasmodium falciparum is highly polymorphic. Such variation might be utilized by the parasite to escape from or interfere with CD4 T cell effector functions. Here, we show that costimulation with naturally occurring altered peptide ligands (APL) can induce a rapid change from IFNγ production to the immunosuppressive mediator interleukin 10 (IL- 10). This mechanism may contribute to the low levels of T cell responses observed to this pathogen in malaria-endemic areas.

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AN - SCOPUS:0033152407

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EP - 660

JO - Immunity

JF - Immunity

IS - 6

ER -

Interleukin 10-mediated immunosuppression by a variant CD4 T cell epitope of Plasmodium falciparum

Abstract

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