Interleukin-10: Is it good or bad for the kidney?

Steven J. Chadban, David J. Nikolic-Paterson

Research output: Contribution to journalReview ArticleResearchpeer-review

4 Citations (Scopus)

Abstract

Interleukin-10 (IL-10) is a cytokine which has been suggested as a possible immunosuppressive treatment for kidney disease. The ability of IL- 10 to suppress antigen presentation to T cells, inhibit the delayed-type hypersensitivity reaction and to inhibit macrophage production of pro- inflammatory cytokines provides a logical basis for its use in the treatment of kidney disease. With the exception of Th1-mediated crescentic glomerulonephritis, however, IL-10 treatment of experimental kidney disease has produced disappointing results largely due to its stimulatory effects upon the humoral immune response, macrophage Fc-receptor expression and macrophage proliferation. Paradoxically, there is now evidence to suggest that endogenous production of IL-10 within the kidney may actually contribute to kidney damage through stimulating mesangial proliferation, immune complex deposition and macrophage infiltration. We await the outcome of studies designed to block IL-10 function in experimental disease models.

Original languageEnglish
Pages (from-to)331-338
Number of pages8
JournalNephrology
Volume4
Issue number5-6
DOIs
Publication statusPublished - 1 Jan 1998
Externally publishedYes

Keywords

  • Cytokine therapy
  • Gene expression
  • Glomerulonephritis
  • Inflammation
  • Interleukin-10
  • Macrophages

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