Interleukin 10 increases CCR5 expression and HIV infection in human monocytes

Silvano Sozzani, Silvia Ghezzi, Gioacchino Iannolo, Walter Luini, Alessandro Borsatti, Nadia Polentarutti, Antonio Sica, Massimo Locati, Charles Mackay, Timothy N.C. Wells, Priscilla Biswas, Elisa Vicenzi, Guido Poli, Alberto Mantovani

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202 Citations (Scopus)

Abstract

The immunosuppressive and antiinflammatory cytokine interleukin (IL) 10 selectively upregulates the expression of the CC chemokine receptors CCR5, 2, and 1 in human monocytes by prolonging their mRNA half-life. IL-10-stimulated monocytes display an increased number of cell surface receptors for, and better chemotactic responsiveness to, relevant agonists than do control cells. In addition, IL-10-stimulated monocytes are more efficiently infected by HIV BaL. This effect was associated to the enhancement of vital entry through CCR5. These data add support to an emerging paradigm in which pro- and antiinflammatory molecules exert reciprocal and opposing influence on chemokine agonist production and receptor expression.

Original languageEnglish
Pages (from-to)439-444
Number of pages6
JournalThe Journal of Experimental Medicine
Volume187
Issue number3
DOIs
Publication statusPublished - 2 Feb 1998
Externally publishedYes

Cite this

Sozzani, S., Ghezzi, S., Iannolo, G., Luini, W., Borsatti, A., Polentarutti, N., ... Mantovani, A. (1998). Interleukin 10 increases CCR5 expression and HIV infection in human monocytes. The Journal of Experimental Medicine, 187(3), 439-444. https://doi.org/10.1084/jem.187.3.439