Interferon-epsilon protects the female reproductive tract from viral and bacterial infection

Ka Yee Fung, Niamh Mangan, Helen Elizabeth Cumming, Jay C Horvat, Jemma R Mayall, Sebastian Anton Stifter, Nicole Anne De Weerd, Laila Catalina Roisman, Jamie Rossjohn, Sarah A Roberston, John E Schjenken, Belinda S Parker, Caroline Eve Gargett, Hong Phuong Thi Nguyen, Daniel J J Carr, Phillip M Hansbro, Paul John Hertzog

Research output: Contribution to journalArticleResearchpeer-review

108 Citations (Scopus)

Abstract

The innate immune system senses pathogens through pattern-recognition receptors (PRRs) that signal to induce effector cytokines, such as type I interferons (IFNs). We characterized IFN-e as a type I IFN because it signaled via the Ifnar1 and Ifnar2 receptors to induce IFN-regulated genes. In contrast to other type I IFNs, IFN-e was not induced by known PRR pathways; instead, IFN-e was constitutively expressed by epithelial cells of the female reproductive tract (FRT) and was hormonally regulated. Ifn-e-deficient mice had increased susceptibility to infection of the FRT by the common sexually transmitted infections (STIs) herpes simplex virus 2 and Chlamydia muridarum. Thus, IFN-e is a potent antipathogen and immunoregulatory cytokine that may be important in combating STIs that represent a major global health and socioeconomic burden.
Original languageEnglish
Pages (from-to)1088 - 1092
Number of pages5
JournalScience
Volume339
Issue number6123
DOIs
Publication statusPublished - 2013

Cite this

Fung, Ka Yee ; Mangan, Niamh ; Cumming, Helen Elizabeth ; Horvat, Jay C ; Mayall, Jemma R ; Stifter, Sebastian Anton ; De Weerd, Nicole Anne ; Roisman, Laila Catalina ; Rossjohn, Jamie ; Roberston, Sarah A ; Schjenken, John E ; Parker, Belinda S ; Gargett, Caroline Eve ; Nguyen, Hong Phuong Thi ; Carr, Daniel J J ; Hansbro, Phillip M ; Hertzog, Paul John. / Interferon-epsilon protects the female reproductive tract from viral and bacterial infection. In: Science. 2013 ; Vol. 339, No. 6123. pp. 1088 - 1092.
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title = "Interferon-epsilon protects the female reproductive tract from viral and bacterial infection",
abstract = "The innate immune system senses pathogens through pattern-recognition receptors (PRRs) that signal to induce effector cytokines, such as type I interferons (IFNs). We characterized IFN-e as a type I IFN because it signaled via the Ifnar1 and Ifnar2 receptors to induce IFN-regulated genes. In contrast to other type I IFNs, IFN-e was not induced by known PRR pathways; instead, IFN-e was constitutively expressed by epithelial cells of the female reproductive tract (FRT) and was hormonally regulated. Ifn-e-deficient mice had increased susceptibility to infection of the FRT by the common sexually transmitted infections (STIs) herpes simplex virus 2 and Chlamydia muridarum. Thus, IFN-e is a potent antipathogen and immunoregulatory cytokine that may be important in combating STIs that represent a major global health and socioeconomic burden.",
author = "Fung, {Ka Yee} and Niamh Mangan and Cumming, {Helen Elizabeth} and Horvat, {Jay C} and Mayall, {Jemma R} and Stifter, {Sebastian Anton} and {De Weerd}, {Nicole Anne} and Roisman, {Laila Catalina} and Jamie Rossjohn and Roberston, {Sarah A} and Schjenken, {John E} and Parker, {Belinda S} and Gargett, {Caroline Eve} and Nguyen, {Hong Phuong Thi} and Carr, {Daniel J J} and Hansbro, {Phillip M} and Hertzog, {Paul John}",
year = "2013",
doi = "10.1126/science.1233321",
language = "English",
volume = "339",
pages = "1088 -- 1092",
journal = "Science",
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Fung, KY, Mangan, N, Cumming, HE, Horvat, JC, Mayall, JR, Stifter, SA, De Weerd, NA, Roisman, LC, Rossjohn, J, Roberston, SA, Schjenken, JE, Parker, BS, Gargett, CE, Nguyen, HPT, Carr, DJJ, Hansbro, PM & Hertzog, PJ 2013, 'Interferon-epsilon protects the female reproductive tract from viral and bacterial infection', Science, vol. 339, no. 6123, pp. 1088 - 1092. https://doi.org/10.1126/science.1233321

Interferon-epsilon protects the female reproductive tract from viral and bacterial infection. / Fung, Ka Yee; Mangan, Niamh; Cumming, Helen Elizabeth; Horvat, Jay C; Mayall, Jemma R; Stifter, Sebastian Anton; De Weerd, Nicole Anne; Roisman, Laila Catalina; Rossjohn, Jamie; Roberston, Sarah A; Schjenken, John E; Parker, Belinda S; Gargett, Caroline Eve; Nguyen, Hong Phuong Thi; Carr, Daniel J J; Hansbro, Phillip M; Hertzog, Paul John.

In: Science, Vol. 339, No. 6123, 2013, p. 1088 - 1092.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Interferon-epsilon protects the female reproductive tract from viral and bacterial infection

AU - Fung, Ka Yee

AU - Mangan, Niamh

AU - Cumming, Helen Elizabeth

AU - Horvat, Jay C

AU - Mayall, Jemma R

AU - Stifter, Sebastian Anton

AU - De Weerd, Nicole Anne

AU - Roisman, Laila Catalina

AU - Rossjohn, Jamie

AU - Roberston, Sarah A

AU - Schjenken, John E

AU - Parker, Belinda S

AU - Gargett, Caroline Eve

AU - Nguyen, Hong Phuong Thi

AU - Carr, Daniel J J

AU - Hansbro, Phillip M

AU - Hertzog, Paul John

PY - 2013

Y1 - 2013

N2 - The innate immune system senses pathogens through pattern-recognition receptors (PRRs) that signal to induce effector cytokines, such as type I interferons (IFNs). We characterized IFN-e as a type I IFN because it signaled via the Ifnar1 and Ifnar2 receptors to induce IFN-regulated genes. In contrast to other type I IFNs, IFN-e was not induced by known PRR pathways; instead, IFN-e was constitutively expressed by epithelial cells of the female reproductive tract (FRT) and was hormonally regulated. Ifn-e-deficient mice had increased susceptibility to infection of the FRT by the common sexually transmitted infections (STIs) herpes simplex virus 2 and Chlamydia muridarum. Thus, IFN-e is a potent antipathogen and immunoregulatory cytokine that may be important in combating STIs that represent a major global health and socioeconomic burden.

AB - The innate immune system senses pathogens through pattern-recognition receptors (PRRs) that signal to induce effector cytokines, such as type I interferons (IFNs). We characterized IFN-e as a type I IFN because it signaled via the Ifnar1 and Ifnar2 receptors to induce IFN-regulated genes. In contrast to other type I IFNs, IFN-e was not induced by known PRR pathways; instead, IFN-e was constitutively expressed by epithelial cells of the female reproductive tract (FRT) and was hormonally regulated. Ifn-e-deficient mice had increased susceptibility to infection of the FRT by the common sexually transmitted infections (STIs) herpes simplex virus 2 and Chlamydia muridarum. Thus, IFN-e is a potent antipathogen and immunoregulatory cytokine that may be important in combating STIs that represent a major global health and socioeconomic burden.

UR - http://www.ncbi.nlm.nih.gov/pubmed/23449591

U2 - 10.1126/science.1233321

DO - 10.1126/science.1233321

M3 - Article

VL - 339

SP - 1088

EP - 1092

JO - Science

JF - Science

SN - 0036-8075

IS - 6123

ER -