Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 7353 - 7369 |
| Number of pages | 17 |
| Journal | Physics in Medicine and Biology |
| Volume | 56 |
| Issue number | 23 |
| DOIs | |
| Publication status | Published - 2011 |
Cite this
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Interface-specific x-ray phase retrieval tomography of complex biological organs. / Beltran, Mario; Paganin, David; Siu, Karen; Fouras, Andreas; Hooper, Stuart; Reser, David; Kitchen, Marcus.
In: Physics in Medicine and Biology, Vol. 56, No. 23, 2011, p. 7353 - 7369.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Interface-specific x-ray phase retrieval tomography of complex biological organs
AU - Beltran, Mario
AU - Paganin, David
AU - Siu, Karen
AU - Fouras, Andreas
AU - Hooper, Stuart
AU - Reser, David
AU - Kitchen, Marcus
PY - 2011
Y1 - 2011
N2 - We demonstrate interface-specific propagation-based x-ray phase retrieval tomography of the thorax and brain of small animals. Our method utilizes a single propagation-based x-ray phase-contrast image per projection, under the assumptions of (i) partially coherent paraxial radiation, (ii) a static object whose refractive indices take on one of a series of distinct values at each point in space and (iii) the projection approximation. For the biological samples used here, there was a 9-200 fold improvement in the signal-to-noise ratio of the phase-retrieved tomograms over the conventional attenuation-contrast signal. The ability to digitally dissect a biological specimen, using only a single phase-contrast image per projection, will be useful for low-dose high-spatial-resolution biomedical imaging of form and biological function in both healthy and diseased tissue.
AB - We demonstrate interface-specific propagation-based x-ray phase retrieval tomography of the thorax and brain of small animals. Our method utilizes a single propagation-based x-ray phase-contrast image per projection, under the assumptions of (i) partially coherent paraxial radiation, (ii) a static object whose refractive indices take on one of a series of distinct values at each point in space and (iii) the projection approximation. For the biological samples used here, there was a 9-200 fold improvement in the signal-to-noise ratio of the phase-retrieved tomograms over the conventional attenuation-contrast signal. The ability to digitally dissect a biological specimen, using only a single phase-contrast image per projection, will be useful for low-dose high-spatial-resolution biomedical imaging of form and biological function in both healthy and diseased tissue.
UR - http://iopscience.iop.org.ezproxy.lib.monash.edu.au/0031-9155/56/23/002/pdf/0031-9155_56_23_002.pdf
U2 - 10.1088/0031-9155/56/23/002
DO - 10.1088/0031-9155/56/23/002
M3 - Article
VL - 56
SP - 7353
EP - 7369
JO - Physics in Medicine and Biology
JF - Physics in Medicine and Biology
SN - 0031-9155
IS - 23
ER -