Interface-specific x-ray phase retrieval tomography of complex biological organs

Mario Beltran, David Paganin, Karen Siu, Andreas Fouras, Stuart Hooper, David Reser, Marcus Kitchen

Research output: Contribution to journalArticleResearchpeer-review

59 Citations (Scopus)

Abstract

We demonstrate interface-specific propagation-based x-ray phase retrieval tomography of the thorax and brain of small animals. Our method utilizes a single propagation-based x-ray phase-contrast image per projection, under the assumptions of (i) partially coherent paraxial radiation, (ii) a static object whose refractive indices take on one of a series of distinct values at each point in space and (iii) the projection approximation. For the biological samples used here, there was a 9-200 fold improvement in the signal-to-noise ratio of the phase-retrieved tomograms over the conventional attenuation-contrast signal. The ability to digitally dissect a biological specimen, using only a single phase-contrast image per projection, will be useful for low-dose high-spatial-resolution biomedical imaging of form and biological function in both healthy and diseased tissue.
Original languageEnglish
Pages (from-to)7353 - 7369
Number of pages17
JournalPhysics in Medicine and Biology
Volume56
Issue number23
DOIs
Publication statusPublished - 2011

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