Intercycle variability of the ovarian response in patients undergoing repeated stimulation with corifollitropin alfa in a gonadotropin-releasing hormone antagonist protocol

Luk Rombauts, Cornelius B Lambalk, Askan Schultze-Mosgau, Jacqueline van Kuijk, Pierre Verweij, Davis Gates, Keith Gordon, Georg Griesinger

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Abstract

To determine whether individual subject variation in ovarian response between repeated cycles with the same ovarian stimulation protocol can be predicted. DESIGN: Retrospective data analysis. SETTING: Multicenter, open-label, uncontrolled clinical trial. PATIENT(S): Women aged 18-39 from a phase 3, open-label, uncontrolled trial with complete data across all cycles (n = 176). INTERVENTION(S): Up to three cycles of a single injection of 150 ?g corifollitropin alfa for 7 days, then daily recombinant FSH/hMG until three follicles reached =17 mm. Gonadotropin-releasing hormone antagonist from stimulation day 5 until day of hCG administration. MAIN OUTCOME MEASURE(S): Numbers of follicles =11 mm on day of hCG in cycles 1-3, transition in ovarian response type between cycles from low (0-
Original languageEnglish
Pages (from-to)884 - 890
Number of pages7
JournalFertility and Sterility
Volume104
Issue number4 (Art. ID: e2)
DOIs
Publication statusPublished - 2015

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