Interatrial Shunt Device for Heart Failure With Preserved Ejection Fraction

David M. Kaye; Shane Nanayakkara

doi:10.3389/fcvm.2019.00143

Interatrial Shunt Device for Heart Failure With Preserved Ejection Fraction

Research output: Contribution to journal › Review Article › Other › peer-review

Abstract

Heart failure with preserved ejection fraction (HFpEF) accounts for approximately half of the current burden of HF, and the prevalence is continuing to rise. In contrast to HF with reduced ejection fraction (HFrEF) there are no clinically effective evidence based therapies for HFpEF. The principal pathophysiologic disorder is an elevation of left atrial pressure, most notable during physical activity, which results from impaired left ventricular diastolic reserve, and increased left atrial stiffness. This review outlines the clinical development of a potential device based therapy for HFpEF, the interatrial shunt device (IASD).

Original language	English
Article number	143
Number of pages	6
Journal	Frontiers in Cardiovascular Medicine
Volume	6
DOIs	https://doi.org/10.3389/fcvm.2019.00143
Publication status	Published - 18 Sept 2019
Externally published	Yes

Keywords

cardiac catheter interventional treatment
clinical trial
diastolic dysfunction
heart failure
structural heart device

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10.3389/fcvm.2019.00143Licence: CC BY

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@article{93b878da0e7e4645ad9a22ffc782aaaf,

title = "Interatrial Shunt Device for Heart Failure With Preserved Ejection Fraction",

abstract = "Heart failure with preserved ejection fraction (HFpEF) accounts for approximately half of the current burden of HF, and the prevalence is continuing to rise. In contrast to HF with reduced ejection fraction (HFrEF) there are no clinically effective evidence based therapies for HFpEF. The principal pathophysiologic disorder is an elevation of left atrial pressure, most notable during physical activity, which results from impaired left ventricular diastolic reserve, and increased left atrial stiffness. This review outlines the clinical development of a potential device based therapy for HFpEF, the interatrial shunt device (IASD).",

keywords = "cardiac catheter interventional treatment, clinical trial, diastolic dysfunction, heart failure, structural heart device",

author = "Kaye, \{David M.\} and Shane Nanayakkara",

note = "Funding Information: SN was supported by a Heart Foundation scholarship, grant number 101116. Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2019 Kaye and Nanayakkara.",

year = "2019",

month = sep,

day = "18",

doi = "10.3389/fcvm.2019.00143",

language = "English",

volume = "6",

journal = "Frontiers in Cardiovascular Medicine",

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TY - JOUR

T1 - Interatrial Shunt Device for Heart Failure With Preserved Ejection Fraction

AU - Kaye, David M.

AU - Nanayakkara, Shane

PY - 2019/9/18

Y1 - 2019/9/18

N2 - Heart failure with preserved ejection fraction (HFpEF) accounts for approximately half of the current burden of HF, and the prevalence is continuing to rise. In contrast to HF with reduced ejection fraction (HFrEF) there are no clinically effective evidence based therapies for HFpEF. The principal pathophysiologic disorder is an elevation of left atrial pressure, most notable during physical activity, which results from impaired left ventricular diastolic reserve, and increased left atrial stiffness. This review outlines the clinical development of a potential device based therapy for HFpEF, the interatrial shunt device (IASD).

AB - Heart failure with preserved ejection fraction (HFpEF) accounts for approximately half of the current burden of HF, and the prevalence is continuing to rise. In contrast to HF with reduced ejection fraction (HFrEF) there are no clinically effective evidence based therapies for HFpEF. The principal pathophysiologic disorder is an elevation of left atrial pressure, most notable during physical activity, which results from impaired left ventricular diastolic reserve, and increased left atrial stiffness. This review outlines the clinical development of a potential device based therapy for HFpEF, the interatrial shunt device (IASD).

KW - cardiac catheter interventional treatment

KW - clinical trial

KW - diastolic dysfunction

KW - heart failure

KW - structural heart device

UR - https://www.scopus.com/pages/publications/85079154694

U2 - 10.3389/fcvm.2019.00143

DO - 10.3389/fcvm.2019.00143

M3 - Review Article

C2 - 31620452

AN - SCOPUS:85079154694

SN - 2297-055X

VL - 6

JO - Frontiers in Cardiovascular Medicine

JF - Frontiers in Cardiovascular Medicine

M1 - 143

ER -

Interatrial Shunt Device for Heart Failure With Preserved Ejection Fraction

Abstract

Keywords

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