Interactions of mean body and local skin temperatures in the modulation of human forearm and calf blood flows: a three-dimensional description

Joanne N. Caldwell, Mayumi Matsuda-Nakamura, Nigel A S Taylor

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Abstract

AIM: The inter-relationships between mean body and local skin temperatures have previously been established for controlling hand and foot blood flows. Since glabrous skin contains many arteriovenous anastomoses, it was important to repeat those experiments on non-glabrous regions using the same sample and experimental conditions. METHODS: Mild hypothermia (mean body temperature 31.4 degrees C), normothermia (control: 36.0 degrees C) and moderate hyperthermia (38.3 degrees C) were induced and clamped (climate chamber and water-perfusion garment) in eight males. Within each condition, five localised thermal treatments (5, 15, 25, 33, 40 degrees C) were applied to the left forearm and right calf. Steady-state forearm and calf blood flows were measured (venous occlusion plethysmography) for each of the resulting 15 combinations of clamped mean body and local skin temperatures. RESULTS: Under the normothermic clamp, cutaneous blood flows averaged 4.2 mL 100 mL(-1) min(-1) (+/-0.28: forearm) and 5.4 mL 100 mL(-1) min(-1) (+/-0.27: calf). When mildly hypothermic, these segments were unresponsive to localised thermal stimuli, but tracked those changes when normothermic and moderately hyperthermic. For deep-body (oesophageal) temperature elevations, forearm blood flow increased by 5.1 mL 100 mL(-1) min(-1) degrees C(-1) (+/-0.9) relative to normothermia, while the calf was much less responsive: 3.3 mL 100 mL(-1) min(-1) degrees C(-1) (+/-1.5). Three-dimensional surfaces revealed a qualitative divergence in the control of calf blood flow, with vasoconstrictor tone apparently being released more gradually. CONCLUSION: These descriptions reinforce the importance of deep-tissue temperatures in controlling cutaneous perfusion, with this modulation being non-linear at the forearm and appearing linear for the calf.
Original languageEnglish
Pages (from-to)343-352
Number of pages10
JournalEuropean Journal of Applied Physiology
Volume116
Issue number2
DOIs
Publication statusPublished - Feb 2016
Externally publishedYes

Cite this

@article{2897227af39a4eb89b6fb79b5a2ee4e1,
title = "Interactions of mean body and local skin temperatures in the modulation of human forearm and calf blood flows: a three-dimensional description",
abstract = "AIM: The inter-relationships between mean body and local skin temperatures have previously been established for controlling hand and foot blood flows. Since glabrous skin contains many arteriovenous anastomoses, it was important to repeat those experiments on non-glabrous regions using the same sample and experimental conditions. METHODS: Mild hypothermia (mean body temperature 31.4 degrees C), normothermia (control: 36.0 degrees C) and moderate hyperthermia (38.3 degrees C) were induced and clamped (climate chamber and water-perfusion garment) in eight males. Within each condition, five localised thermal treatments (5, 15, 25, 33, 40 degrees C) were applied to the left forearm and right calf. Steady-state forearm and calf blood flows were measured (venous occlusion plethysmography) for each of the resulting 15 combinations of clamped mean body and local skin temperatures. RESULTS: Under the normothermic clamp, cutaneous blood flows averaged 4.2 mL 100 mL(-1) min(-1) (+/-0.28: forearm) and 5.4 mL 100 mL(-1) min(-1) (+/-0.27: calf). When mildly hypothermic, these segments were unresponsive to localised thermal stimuli, but tracked those changes when normothermic and moderately hyperthermic. For deep-body (oesophageal) temperature elevations, forearm blood flow increased by 5.1 mL 100 mL(-1) min(-1) degrees C(-1) (+/-0.9) relative to normothermia, while the calf was much less responsive: 3.3 mL 100 mL(-1) min(-1) degrees C(-1) (+/-1.5). Three-dimensional surfaces revealed a qualitative divergence in the control of calf blood flow, with vasoconstrictor tone apparently being released more gradually. CONCLUSION: These descriptions reinforce the importance of deep-tissue temperatures in controlling cutaneous perfusion, with this modulation being non-linear at the forearm and appearing linear for the calf.",
author = "Caldwell, {Joanne N.} and Mayumi Matsuda-Nakamura and Taylor, {Nigel A S}",
year = "2016",
month = "2",
doi = "10.1007/s00421-015-3288-4",
language = "English",
volume = "116",
pages = "343--352",
journal = "European Journal of Applied Physiology",
issn = "1439-6319",
publisher = "Springer-Verlag London Ltd.",
number = "2",

}

Interactions of mean body and local skin temperatures in the modulation of human forearm and calf blood flows: a three-dimensional description. / Caldwell, Joanne N.; Matsuda-Nakamura, Mayumi; Taylor, Nigel A S.

In: European Journal of Applied Physiology, Vol. 116, No. 2, 02.2016, p. 343-352.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Interactions of mean body and local skin temperatures in the modulation of human forearm and calf blood flows: a three-dimensional description

AU - Caldwell, Joanne N.

AU - Matsuda-Nakamura, Mayumi

AU - Taylor, Nigel A S

PY - 2016/2

Y1 - 2016/2

N2 - AIM: The inter-relationships between mean body and local skin temperatures have previously been established for controlling hand and foot blood flows. Since glabrous skin contains many arteriovenous anastomoses, it was important to repeat those experiments on non-glabrous regions using the same sample and experimental conditions. METHODS: Mild hypothermia (mean body temperature 31.4 degrees C), normothermia (control: 36.0 degrees C) and moderate hyperthermia (38.3 degrees C) were induced and clamped (climate chamber and water-perfusion garment) in eight males. Within each condition, five localised thermal treatments (5, 15, 25, 33, 40 degrees C) were applied to the left forearm and right calf. Steady-state forearm and calf blood flows were measured (venous occlusion plethysmography) for each of the resulting 15 combinations of clamped mean body and local skin temperatures. RESULTS: Under the normothermic clamp, cutaneous blood flows averaged 4.2 mL 100 mL(-1) min(-1) (+/-0.28: forearm) and 5.4 mL 100 mL(-1) min(-1) (+/-0.27: calf). When mildly hypothermic, these segments were unresponsive to localised thermal stimuli, but tracked those changes when normothermic and moderately hyperthermic. For deep-body (oesophageal) temperature elevations, forearm blood flow increased by 5.1 mL 100 mL(-1) min(-1) degrees C(-1) (+/-0.9) relative to normothermia, while the calf was much less responsive: 3.3 mL 100 mL(-1) min(-1) degrees C(-1) (+/-1.5). Three-dimensional surfaces revealed a qualitative divergence in the control of calf blood flow, with vasoconstrictor tone apparently being released more gradually. CONCLUSION: These descriptions reinforce the importance of deep-tissue temperatures in controlling cutaneous perfusion, with this modulation being non-linear at the forearm and appearing linear for the calf.

AB - AIM: The inter-relationships between mean body and local skin temperatures have previously been established for controlling hand and foot blood flows. Since glabrous skin contains many arteriovenous anastomoses, it was important to repeat those experiments on non-glabrous regions using the same sample and experimental conditions. METHODS: Mild hypothermia (mean body temperature 31.4 degrees C), normothermia (control: 36.0 degrees C) and moderate hyperthermia (38.3 degrees C) were induced and clamped (climate chamber and water-perfusion garment) in eight males. Within each condition, five localised thermal treatments (5, 15, 25, 33, 40 degrees C) were applied to the left forearm and right calf. Steady-state forearm and calf blood flows were measured (venous occlusion plethysmography) for each of the resulting 15 combinations of clamped mean body and local skin temperatures. RESULTS: Under the normothermic clamp, cutaneous blood flows averaged 4.2 mL 100 mL(-1) min(-1) (+/-0.28: forearm) and 5.4 mL 100 mL(-1) min(-1) (+/-0.27: calf). When mildly hypothermic, these segments were unresponsive to localised thermal stimuli, but tracked those changes when normothermic and moderately hyperthermic. For deep-body (oesophageal) temperature elevations, forearm blood flow increased by 5.1 mL 100 mL(-1) min(-1) degrees C(-1) (+/-0.9) relative to normothermia, while the calf was much less responsive: 3.3 mL 100 mL(-1) min(-1) degrees C(-1) (+/-1.5). Three-dimensional surfaces revealed a qualitative divergence in the control of calf blood flow, with vasoconstrictor tone apparently being released more gradually. CONCLUSION: These descriptions reinforce the importance of deep-tissue temperatures in controlling cutaneous perfusion, with this modulation being non-linear at the forearm and appearing linear for the calf.

UR - http://www.ncbi.nlm.nih.gov/pubmed/26526291

U2 - 10.1007/s00421-015-3288-4

DO - 10.1007/s00421-015-3288-4

M3 - Article

VL - 116

SP - 343

EP - 352

JO - European Journal of Applied Physiology

JF - European Journal of Applied Physiology

SN - 1439-6319

IS - 2

ER -