Interactions of angiotensin II with central dopamine

T. A. Jenkins, A. M. Allen, S. Y. Chai, D. P. MacGregor, G. Paxinos, F. A.O. Mendelsohn

Research output: Contribution to journalReview ArticleResearchpeer-review

44 Citations (Scopus)


There is a large body of evidence to support the concept of a relationship between brain Ang II and catecholamine systems. This interaction may participate in some central actions of Ang II such as cardiovascular control, dipsogenesis, and complex behaviours. It also extends to the nigrostriatal dopaminergic system which bear AT1 receptors, both on their cell bodies in the substantia nigra presynaptically, and on their terminals in the striatum, where Ang II can markedly potentiate DA release. This observation suggests that drugs which modulate central Ang II may be useful in regulating central dopaminergic activity.

Original languageEnglish
Pages (from-to)93-103
Number of pages11
JournalAdvances in Experimental Medicine and Biology
Publication statusPublished - 7 Jun 1996
Externally publishedYes

Cite this

Jenkins, T. A., Allen, A. M., Chai, S. Y., MacGregor, D. P., Paxinos, G., & Mendelsohn, F. A. O. (1996). Interactions of angiotensin II with central dopamine. Advances in Experimental Medicine and Biology, 396, 93-103.