Interactions between bacteriophage, bacteria, and the mammalian immune system

Jonas D. Van Belleghem, Krystyna Dąbrowska, Mario Vaneechoutte, Jeremy J. Barr, Paul L. Bollyky

Research output: Contribution to journalReview ArticleResearchpeer-review

216 Citations (Scopus)


The human body is host to large numbers of bacteriophages (phages)–a diverse group of bacterial viruses that infect bacteria. Phage were previously regarded as bystanders that only impacted immunity indirectly via effects on the mammalian microbiome. However, it has become clear that phages also impact immunity directly, in ways that are typically anti-inflammatory. Phages can modulate innate immunity via phagocytosis and cytokine responses, but also impact adaptive immunity via effects on antibody production and effector polarization. Phages may thereby have profound effects on the outcome of bacterial infections by modulating the immune response. In this review we highlight the diverse ways in which phages interact with human cells. We present a computational model for predicting these complex and dynamic interactions. These models predict that the phageome may play important roles in shaping mammalian-bacterial interactions.

Original languageEnglish
Article number10
Number of pages22
Issue number1
Publication statusPublished - 1 Jan 2019


  • Adaptive immunity
  • Bacteriophage
  • Human host
  • Immunology
  • Innate immunity
  • Phage-human host interaction

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