Interactions between ambient air pollution and obesity on lung function in children: The Seven Northeastern Chinese Cities (SNEC) Study

Xiumei Xing, Liwen Hu, Yuming Guo, Michael S. Bloom, Shanshan Li, Gongbo Chen, Steve Hung Lam Yim, Namratha Gurram, Mo Yang, Xiang Xiao, Shuli Xu, Qi Wei, Hongyao Yu, Boyi Yang, Xiaowen Zeng, Wen Chen, Qiang Hu, Guanghui Dong

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Abstract

Children are vulnerable to air pollution-induced lung function deficits, and the prevalence of obesity has been increasing in children. To evaluate the joint effects of long-term PM1 (particulate matter with an aerodynamic diameter ≤ 1.0 μm) exposure and obesity on children's lung function, a cross-sectional sample of 6740 children (aged 7–14 years) was enrolled across seven northeastern Chinese cities from 2012 to 2013. Weight and lung function, including forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), peak expiratory flow (PEF), and maximal mid-expiratory flow (MMEF), were measured according to standardized protocols. Average PM1, PM2.5, PM10 and nitrogen dioxide (NO2) exposure levels were estimated using a spatiotemporal model, and sulphur dioxide (SO2) and ozone (O3) exposure were estimated using data from municipal air monitoring stations. Two-level logistic regression and general linear models were used to analyze the joint effects of body mass index (BMI) and air pollutants. The results showed that long-term air pollution exposure was associated with lung function impairment and there were significant interactions with BMI. Associations were stronger among obese and overweight than normal weight participants (the adjusted odds ratios (95% confidence intervals) for PM1 and lung function impairments in three increasing BMI categories were 1.50 (1.07–2.11) to 2.55 (1.59–4.07) for FVC < 85% predicted, 1.44 (1.03–2.01) to 2.51 (1.53–4.11) for FEV1 < 85% predicted, 1.34 (0.97–1.84) to 2.04 (1.24–3.35) for PEF < 75% predicted, and 1.34 (1.01–1.78) to 1.93 (1.26–2.95) for MMEF < 75% predicted). Consistent results were detected in linear regression models for PM1, PM2.5 and SO2 on FVC and FEV1 impairments (PInteraction < 0.05). These modification effects were stronger among females and older participants. These results can provide policy makers with more comprehensive information for to develop strategies for preventing air pollution induced children's lung function deficits among children.

Original languageEnglish
Article number134397
Number of pages10
JournalScience of the Total Environment
Volume699
DOIs
Publication statusPublished - 10 Jan 2020

Keywords

  • Air pollution
  • Children
  • Lung function
  • Obesity
  • Particulate matter

Cite this

Xing, Xiumei ; Hu, Liwen ; Guo, Yuming ; Bloom, Michael S. ; Li, Shanshan ; Chen, Gongbo ; Yim, Steve Hung Lam ; Gurram, Namratha ; Yang, Mo ; Xiao, Xiang ; Xu, Shuli ; Wei, Qi ; Yu, Hongyao ; Yang, Boyi ; Zeng, Xiaowen ; Chen, Wen ; Hu, Qiang ; Dong, Guanghui. / Interactions between ambient air pollution and obesity on lung function in children : The Seven Northeastern Chinese Cities (SNEC) Study. In: Science of the Total Environment. 2020 ; Vol. 699.
@article{1ce2fdc9a7ab47e5938a3c2f7827b60f,
title = "Interactions between ambient air pollution and obesity on lung function in children: The Seven Northeastern Chinese Cities (SNEC) Study",
abstract = "Children are vulnerable to air pollution-induced lung function deficits, and the prevalence of obesity has been increasing in children. To evaluate the joint effects of long-term PM1 (particulate matter with an aerodynamic diameter ≤ 1.0 μm) exposure and obesity on children's lung function, a cross-sectional sample of 6740 children (aged 7–14 years) was enrolled across seven northeastern Chinese cities from 2012 to 2013. Weight and lung function, including forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), peak expiratory flow (PEF), and maximal mid-expiratory flow (MMEF), were measured according to standardized protocols. Average PM1, PM2.5, PM10 and nitrogen dioxide (NO2) exposure levels were estimated using a spatiotemporal model, and sulphur dioxide (SO2) and ozone (O3) exposure were estimated using data from municipal air monitoring stations. Two-level logistic regression and general linear models were used to analyze the joint effects of body mass index (BMI) and air pollutants. The results showed that long-term air pollution exposure was associated with lung function impairment and there were significant interactions with BMI. Associations were stronger among obese and overweight than normal weight participants (the adjusted odds ratios (95{\%} confidence intervals) for PM1 and lung function impairments in three increasing BMI categories were 1.50 (1.07–2.11) to 2.55 (1.59–4.07) for FVC < 85{\%} predicted, 1.44 (1.03–2.01) to 2.51 (1.53–4.11) for FEV1 < 85{\%} predicted, 1.34 (0.97–1.84) to 2.04 (1.24–3.35) for PEF < 75{\%} predicted, and 1.34 (1.01–1.78) to 1.93 (1.26–2.95) for MMEF < 75{\%} predicted). Consistent results were detected in linear regression models for PM1, PM2.5 and SO2 on FVC and FEV1 impairments (PInteraction < 0.05). These modification effects were stronger among females and older participants. These results can provide policy makers with more comprehensive information for to develop strategies for preventing air pollution induced children's lung function deficits among children.",
keywords = "Air pollution, Children, Lung function, Obesity, Particulate matter",
author = "Xiumei Xing and Liwen Hu and Yuming Guo and Bloom, {Michael S.} and Shanshan Li and Gongbo Chen and Yim, {Steve Hung Lam} and Namratha Gurram and Mo Yang and Xiang Xiao and Shuli Xu and Qi Wei and Hongyao Yu and Boyi Yang and Xiaowen Zeng and Wen Chen and Qiang Hu and Guanghui Dong",
year = "2020",
month = "1",
day = "10",
doi = "10.1016/j.scitotenv.2019.134397",
language = "English",
volume = "699",
journal = "Science of the Total Environment",
issn = "0048-9697",
publisher = "Elsevier",

}

Xing, X, Hu, L, Guo, Y, Bloom, MS, Li, S, Chen, G, Yim, SHL, Gurram, N, Yang, M, Xiao, X, Xu, S, Wei, Q, Yu, H, Yang, B, Zeng, X, Chen, W, Hu, Q & Dong, G 2020, 'Interactions between ambient air pollution and obesity on lung function in children: The Seven Northeastern Chinese Cities (SNEC) Study', Science of the Total Environment, vol. 699, 134397. https://doi.org/10.1016/j.scitotenv.2019.134397

Interactions between ambient air pollution and obesity on lung function in children : The Seven Northeastern Chinese Cities (SNEC) Study. / Xing, Xiumei; Hu, Liwen; Guo, Yuming; Bloom, Michael S.; Li, Shanshan; Chen, Gongbo; Yim, Steve Hung Lam; Gurram, Namratha; Yang, Mo; Xiao, Xiang; Xu, Shuli; Wei, Qi; Yu, Hongyao; Yang, Boyi; Zeng, Xiaowen; Chen, Wen; Hu, Qiang; Dong, Guanghui.

In: Science of the Total Environment, Vol. 699, 134397, 10.01.2020.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Interactions between ambient air pollution and obesity on lung function in children

T2 - The Seven Northeastern Chinese Cities (SNEC) Study

AU - Xing, Xiumei

AU - Hu, Liwen

AU - Guo, Yuming

AU - Bloom, Michael S.

AU - Li, Shanshan

AU - Chen, Gongbo

AU - Yim, Steve Hung Lam

AU - Gurram, Namratha

AU - Yang, Mo

AU - Xiao, Xiang

AU - Xu, Shuli

AU - Wei, Qi

AU - Yu, Hongyao

AU - Yang, Boyi

AU - Zeng, Xiaowen

AU - Chen, Wen

AU - Hu, Qiang

AU - Dong, Guanghui

PY - 2020/1/10

Y1 - 2020/1/10

N2 - Children are vulnerable to air pollution-induced lung function deficits, and the prevalence of obesity has been increasing in children. To evaluate the joint effects of long-term PM1 (particulate matter with an aerodynamic diameter ≤ 1.0 μm) exposure and obesity on children's lung function, a cross-sectional sample of 6740 children (aged 7–14 years) was enrolled across seven northeastern Chinese cities from 2012 to 2013. Weight and lung function, including forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), peak expiratory flow (PEF), and maximal mid-expiratory flow (MMEF), were measured according to standardized protocols. Average PM1, PM2.5, PM10 and nitrogen dioxide (NO2) exposure levels were estimated using a spatiotemporal model, and sulphur dioxide (SO2) and ozone (O3) exposure were estimated using data from municipal air monitoring stations. Two-level logistic regression and general linear models were used to analyze the joint effects of body mass index (BMI) and air pollutants. The results showed that long-term air pollution exposure was associated with lung function impairment and there were significant interactions with BMI. Associations were stronger among obese and overweight than normal weight participants (the adjusted odds ratios (95% confidence intervals) for PM1 and lung function impairments in three increasing BMI categories were 1.50 (1.07–2.11) to 2.55 (1.59–4.07) for FVC < 85% predicted, 1.44 (1.03–2.01) to 2.51 (1.53–4.11) for FEV1 < 85% predicted, 1.34 (0.97–1.84) to 2.04 (1.24–3.35) for PEF < 75% predicted, and 1.34 (1.01–1.78) to 1.93 (1.26–2.95) for MMEF < 75% predicted). Consistent results were detected in linear regression models for PM1, PM2.5 and SO2 on FVC and FEV1 impairments (PInteraction < 0.05). These modification effects were stronger among females and older participants. These results can provide policy makers with more comprehensive information for to develop strategies for preventing air pollution induced children's lung function deficits among children.

AB - Children are vulnerable to air pollution-induced lung function deficits, and the prevalence of obesity has been increasing in children. To evaluate the joint effects of long-term PM1 (particulate matter with an aerodynamic diameter ≤ 1.0 μm) exposure and obesity on children's lung function, a cross-sectional sample of 6740 children (aged 7–14 years) was enrolled across seven northeastern Chinese cities from 2012 to 2013. Weight and lung function, including forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), peak expiratory flow (PEF), and maximal mid-expiratory flow (MMEF), were measured according to standardized protocols. Average PM1, PM2.5, PM10 and nitrogen dioxide (NO2) exposure levels were estimated using a spatiotemporal model, and sulphur dioxide (SO2) and ozone (O3) exposure were estimated using data from municipal air monitoring stations. Two-level logistic regression and general linear models were used to analyze the joint effects of body mass index (BMI) and air pollutants. The results showed that long-term air pollution exposure was associated with lung function impairment and there were significant interactions with BMI. Associations were stronger among obese and overweight than normal weight participants (the adjusted odds ratios (95% confidence intervals) for PM1 and lung function impairments in three increasing BMI categories were 1.50 (1.07–2.11) to 2.55 (1.59–4.07) for FVC < 85% predicted, 1.44 (1.03–2.01) to 2.51 (1.53–4.11) for FEV1 < 85% predicted, 1.34 (0.97–1.84) to 2.04 (1.24–3.35) for PEF < 75% predicted, and 1.34 (1.01–1.78) to 1.93 (1.26–2.95) for MMEF < 75% predicted). Consistent results were detected in linear regression models for PM1, PM2.5 and SO2 on FVC and FEV1 impairments (PInteraction < 0.05). These modification effects were stronger among females and older participants. These results can provide policy makers with more comprehensive information for to develop strategies for preventing air pollution induced children's lung function deficits among children.

KW - Air pollution

KW - Children

KW - Lung function

KW - Obesity

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