Interaction of lipid vesicle with silver nanoparticle-serum albumin protein corona

Ran Chen, Poonam Choudhary, Ryan N. Schurr, Priyanka Bhattacharya, Jared M. Brown, Pu Chun Ke

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The physical interaction between a lipid vesicle and a silver nanoparticle (AgNP)-human serum albumin (HSA) protein corona has been examined. Specifically, the binding of AgNPs and HSA was analyzed by spectrophotometry, and the induced conformational changes of the HSA were inferred from circular dichroism spectroscopy. The fluidity of the vesicle, a model system for mimicking cell membrane, was found to increase with the increased exposure to AgNP-HSA corona, though less pronounced compared to that induced by AgNPs alone. This study offers additional information for understanding the role of physical forces in nanoparticle-cell interaction and has implications for nanomedicine and nanotoxicology.

Original languageEnglish
Article number013703
JournalApplied Physics Letters
Issue number1
Publication statusPublished - 2 Jan 2012
Externally publishedYes

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