Intensive care sedation: The past, present and the future

Yahya Shehabi, Rinaldo Bellomo, Sangeeta Mehta, Richard R Riker, Jukka Takala

Research output: Contribution to journalArticleResearchpeer-review

50 Citations (Scopus)


Despite the universal prescription of sedative drugs in the intensive care unit (ICU), current practice is not guided by high-level evidence. Landmark sedation trials have made significant contributions to our understanding of the problems associated with ICU sedation and have promoted changes to current practice. We identified challenges and limitations of clinical trials which reduced the generalizability and the universal adoption of key interventions. We present an international perspective regarding current sedation practice and a blueprint for future research, which seeks to avoid known limitations and generate much-needed high-level evidence to better guide clinicians' management and therapeutic choices of sedative agents.

Original languageEnglish
Article number322
JournalCritical Care
Issue number3
Publication statusPublished - 12 Jun 2013
Externally publishedYes

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