Intensities of renal replacement therapy in acute kidney injury: a systematic review and meta-analysis

Min Jun, Hiddo Lambers Heerspink, Toshiharu Ninomiya, Martin P Gallagher, Rinaldo Bellomo, John A Myburgh, Simon R Finfer, Paul M Palevsky, John A Kellum, Vlado Perkovic, Alan Cass

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Clinical trials of the intensity of renal replacement therapy (RRT) for people with acute kidney injury (AKI) have produced conflicting results. A systematic review and meta-analysis was undertaken to assess the effect of different intensities of RRT on all-cause mortality and renal recovery in AKI patients. Design, setting, participants, measurements: MEDLINE, EMBASE, and the Cochrane Library database were systematically searched for trials published between 1950 and 2009. Inclusion criteria were completed, prospective, adult-population, randomized controlled studies. Relative risks (RRs) and 95 confidence intervals (CIs) were calculated. Summary estimates of RR were obtained using a random effects model. Heterogeneity, metaregression, publication bias, and subgroup analyses were conducted.
Original languageEnglish
Pages (from-to)956 - 963
Number of pages8
JournalClinical Journal of the American Society of Nephrology
Issue number6
Publication statusPublished - 2010
Externally publishedYes

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