Integrin-mediated type IV secretion by Helicobacter: What makes it tick?

Ralf Schuelein, Paige Everingham, Terry Kwok

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Abstract

Helicobacter pylori (Hp) employs a multi-component type IV secretion system (T4SS) to secrete the effector protein CagA into the cytosol of infected host cells. A longstanding challenge has been to identify the host cell receptor(s) involved. Two recent studies have independently unveiled human beta(1) integrin as the receptor but are divided over which T4SS proteins bind to beta(1) integrin. Here we revisit the two models in light of previous findings and recent progress in the field. More concerted efforts are required to fully understand the complex T4SS mechanisms that underpin Hp pathogenesis.
Original languageEnglish
Pages (from-to)211 - 216
Number of pages6
JournalTrends in Microbiology
Volume19
Issue number5
DOIs
Publication statusPublished - 2011

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