TY - JOUR
T1 - Integration of intracellular signaling
T2 - Biological analogues of wires, processors and memories organized by a centrosome 3D reference system
AU - Barvitenko, Nadezhda
AU - Lawen, Alfons
AU - Aslam, Muhammad
AU - Pantaleo, Antonella
AU - Saldanha, Carlota
AU - Skverchinskaya, Elisaveta
AU - Regolini, Marco
AU - Tuszynski, Jack A.
PY - 2018/11
Y1 - 2018/11
N2 - Background: Myriads of signaling pathways in a single cell function to achieve the highest spatio-temporal integration. Data are accumulating on the role of electromechanical soliton-like waves in signal transduction processes. Theoretical studies strongly suggest feasibility of both classical and quantum computing involving microtubules. Aim: A theoretical study of the role of the complex composed of the plasma membrane and the microtubule-based cytoskeleton as a system that transmits, stores and processes information. Methods: Theoretical analysis presented here refers to (i) the Penrose–Hameroff theory of consciousness (Orchestrated Objective Reduction; Orch OR), (ii) the description of the centrosome as a reference system for construction of the 3D map of the cell proposed by Regolini, (iii) the Heimburg–Jackson model of the nerve pulse propagation along axons’ lipid bilayer as soliton-like electro-mechanical waves. Results and conclusion: The ideas presented in this paper provide a qualitative model for the decision-making processes in a living cell undergoing a differentiation process. Outlook: This paper paves the way for the real-time live-cell observation of information processing by microtubule-based cytoskeleton and cell fate decision making.
AB - Background: Myriads of signaling pathways in a single cell function to achieve the highest spatio-temporal integration. Data are accumulating on the role of electromechanical soliton-like waves in signal transduction processes. Theoretical studies strongly suggest feasibility of both classical and quantum computing involving microtubules. Aim: A theoretical study of the role of the complex composed of the plasma membrane and the microtubule-based cytoskeleton as a system that transmits, stores and processes information. Methods: Theoretical analysis presented here refers to (i) the Penrose–Hameroff theory of consciousness (Orchestrated Objective Reduction; Orch OR), (ii) the description of the centrosome as a reference system for construction of the 3D map of the cell proposed by Regolini, (iii) the Heimburg–Jackson model of the nerve pulse propagation along axons’ lipid bilayer as soliton-like electro-mechanical waves. Results and conclusion: The ideas presented in this paper provide a qualitative model for the decision-making processes in a living cell undergoing a differentiation process. Outlook: This paper paves the way for the real-time live-cell observation of information processing by microtubule-based cytoskeleton and cell fate decision making.
KW - Centrosome
KW - Memory
KW - Microtubule
KW - Signal transduction
KW - Signaling
KW - Tubulin
UR - http://www.scopus.com/inward/record.url?scp=85054543194&partnerID=8YFLogxK
U2 - 10.1016/j.biosystems.2018.08.007
DO - 10.1016/j.biosystems.2018.08.007
M3 - Article
AN - SCOPUS:85054543194
VL - 173
SP - 191
EP - 206
JO - Bio Systems
JF - Bio Systems
SN - 0303-2647
ER -