Insulin potentiating action of a peptide fraction from human urine

F. M. Ng, P. Z. Zimmet, G. Seiler, P. Taft, J. Bornstein

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An impure peptide preparation from human urine was shown to have similar biological effects in vitro and in vivo to synthetic peptides containing the human growth hormone sequence Leu Ser Arg Leu Phe Asp Asn Ala (residues 6-13). The urinary preparation potentiates the action of insulin in the isolated rat diaphragm and in rabbits and rats, but the latter animals are far more sensitive to its action. Species specificity is possibly a significant factor in determining dosage in future studies.

Original languageEnglish
Pages (from-to)950-956
Number of pages7
JournalHormone and Metabolic Research
Issue number12
Publication statusPublished - 1974

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