TY - JOUR
T1 - INSULIN HYPOGLYCAEMIA AND CHOLINERGIC BLOCKADE
T2 - RESPONSE OF PLASMA IMMUNOREACTIVE β‐ENDORPHIN
AU - COPOLOV, D.
AU - JETHWA, J.
AU - STERN, A.
AU - CLEMENTS, J.
AU - FUNDER, J. W.
PY - 1983/1/1
Y1 - 1983/1/1
N2 - Six normal subjects were studied to investigate the mechanisms involved in the release of immunoreactive β‐endorphin (ir‐βEP) in response to insulin hypoglycaemia. Insulin alone (0·2 U/kg body weight) was followed after a 30 min lag period by a ≃ 2·5 fold elevation of plasma ir‐βEP, with a return to basal levels by 90 min. Concurrent infusion of 10% dextrose at 250 ml/h for 2 h prevented the increase in plasma ir‐βEP levels, suggesting an effect of hypoglycaemia rather than a direct effect of insulin. Premedication with atropine 0·6 mg at ‐30 min was followed by hypoglycaemia equivalent to that seen with insulin alone, but no increase in plasma ir‐βEP, suggesting the involvement of cholinergic mechanisms in the neural mediation of ir‐βEP release in response to hypoglycaemia.
AB - Six normal subjects were studied to investigate the mechanisms involved in the release of immunoreactive β‐endorphin (ir‐βEP) in response to insulin hypoglycaemia. Insulin alone (0·2 U/kg body weight) was followed after a 30 min lag period by a ≃ 2·5 fold elevation of plasma ir‐βEP, with a return to basal levels by 90 min. Concurrent infusion of 10% dextrose at 250 ml/h for 2 h prevented the increase in plasma ir‐βEP levels, suggesting an effect of hypoglycaemia rather than a direct effect of insulin. Premedication with atropine 0·6 mg at ‐30 min was followed by hypoglycaemia equivalent to that seen with insulin alone, but no increase in plasma ir‐βEP, suggesting the involvement of cholinergic mechanisms in the neural mediation of ir‐βEP release in response to hypoglycaemia.
UR - http://www.scopus.com/inward/record.url?scp=0021084064&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2265.1983.tb00033.x
DO - 10.1111/j.1365-2265.1983.tb00033.x
M3 - Article
C2 - 6315263
AN - SCOPUS:0021084064
SN - 0300-0664
VL - 19
SP - 575
EP - 580
JO - Clinical Endocrinology
JF - Clinical Endocrinology
IS - 5
ER -