Insulin and new bone formation in diffuse idiopathic skeletal hyperostosis

G. O. Littlejohn

doi:10.1007/BF02031611

Insulin and new bone formation in diffuse idiopathic skeletal hyperostosis

G. O. Littlejohn

Medicine Monash Health

Research output: Contribution to journal › Article › Research › peer-review

65 Citations (Scopus)

Abstract

The tendency of patients with DISH towards obesity or an adult onset of diabetes has been reflected in marked hyperinsulinaemia following glucose challenge. It is hypothesized that insulin at prolonged and high physiologic levels promotes new bone growth, particularly in the entheseal regions. These areas are also subject to various mechanical forces. The resulting new bone produces the radiological changes which characterise DISH.

Original language	English
Pages (from-to)	294-300
Number of pages	7
Journal	Clinical Rheumatology
Volume	4
Issue number	3
DOIs	https://doi.org/10.1007/BF02031611
Publication status	Published - 1 Sept 1985

Keywords

DISH
Hyperostosis
Insulin
New Bone Formation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/BF02031611

Cite this

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abstract = "The tendency of patients with DISH towards obesity or an adult onset of diabetes has been reflected in marked hyperinsulinaemia following glucose challenge. It is hypothesized that insulin at prolonged and high physiologic levels promotes new bone growth, particularly in the entheseal regions. These areas are also subject to various mechanical forces. The resulting new bone produces the radiological changes which characterise DISH.",

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AB - The tendency of patients with DISH towards obesity or an adult onset of diabetes has been reflected in marked hyperinsulinaemia following glucose challenge. It is hypothesized that insulin at prolonged and high physiologic levels promotes new bone growth, particularly in the entheseal regions. These areas are also subject to various mechanical forces. The resulting new bone produces the radiological changes which characterise DISH.

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KW - Hyperostosis

KW - Insulin

KW - New Bone Formation

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Insulin and new bone formation in diffuse idiopathic skeletal hyperostosis

Abstract

Keywords

UN SDGs

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