Abstract
A growing body of evidence from research in rodents and humans has identified insulin as an important neuoregulatory peptide in the brain, where it coordinates diverse aspects of energy balance and peripheral glucose homeostasis. This review discusses where and how insulin interacts within the brain and evaluates the physiological and pathophysiological consequences of central insulin signalling in metabolism, obesity and type 2 diabetes.
Original language | English |
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Article number | e12513 |
Number of pages | 13 |
Journal | Journal of Neuroendocrinology |
Volume | 29 |
Issue number | 10 |
DOIs | |
Publication status | Published - 1 Oct 2017 |
Keywords
- AgRP
- energy homeostasis
- glucose homeostasis
- hypothalamus
- insulin
- POMC