Insulin action in the brain: Roles in energy and glucose homeostasis

G. T. Dodd, T. Tiganis

Research output: Contribution to journalReview ArticleOtherpeer-review

20 Citations (Scopus)

Abstract

A growing body of evidence from research in rodents and humans has identified insulin as an important neuoregulatory peptide in the brain, where it coordinates diverse aspects of energy balance and peripheral glucose homeostasis. This review discusses where and how insulin interacts within the brain and evaluates the physiological and pathophysiological consequences of central insulin signalling in metabolism, obesity and type 2 diabetes.

Original languageEnglish
Article numbere12513
Number of pages13
JournalJournal of Neuroendocrinology
Volume29
Issue number10
DOIs
Publication statusPublished - 1 Oct 2017

Keywords

  • AgRP
  • energy homeostasis
  • glucose homeostasis
  • hypothalamus
  • insulin
  • POMC

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