Insights into orphan nuclear receptors as prognostic markers and novel therapeutic targets for breast cancer

Reidun Aesoey, Colin Clyne, Ashwini L Chand

Research output: Contribution to journalArticleResearchpeer-review

Abstract

There is emerging evidence asserting the importance of orphan nuclear receptors (ONRs) in cancer initiation and progression. In breast cancer, there is a lot unknown about ONRs in terms of their expression profile and their transcriptional targets in the various stages of tumor progression. With the classification of breast tumors into distinct molecular subtypes, we assess ONR expression in the different breast cancer subtypes and with patient outcomes. Complementing this, we review evidence implicating ONR-dependent molecular pathways in breast cancer progression to identify candidate ONRs as potential prognostic markers and/or as therapeutic targets.
Original languageEnglish
Article number115
Number of pages11
JournalFrontiers in Endocrinology
Volume6
DOIs
Publication statusPublished - 2015

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