Insights into myelodysplastic syndromes from current preclinical models

Shuh-Ying Tan, Monique F Smeets, Alistair M Chalk, Harshal Nandurkar, Carl R Walkley, Louise E Purton, Meaghan Wall

Research output: Contribution to journalArticleResearchpeer-review


In recent years, there has been significant progress made in our understanding of the molecular genetics of myelodysplastic syndromes (MDS). Using massively parallel sequencing techniques, recurring mutations are identified in up to 80% of MDS cases, including many with a normal karyotype. The differential role of some of these mutations in the initiation and progression of MDS is starting to be elucidated. Engineering candidate genes in mice to model MDS has contributed to recent insights into this complex disease. In this review, we examine currently available mouse models, with detailed discussion of selected models. Finally, we highlight some advances made in our understanding of MDS biology, and conclude with discussions of questions that remain unanswered.
Original languageEnglish
Pages (from-to)1 - 22
Number of pages22
JournalWorld Journal of Hematology
Issue number1
Publication statusPublished - 6 Feb 2016
Externally publishedYes

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