Insights into Acinetobacter baumannii pathogenicity

Gustavo Cerqueira, Anton Peleg

Research output: Contribution to journalArticleResearchpeer-review

87 Citations (Scopus)

Abstract

Acinetobacter spp. have justifiably received significant attention from the public, scientific, and medical communities. Over recent years, Acinetobacter, particularly Acinetobacter baumannii, has become a red-alert human pathogen, primarily because of its exceptional ability to develop resistance to all currently available antibiotics. This characteristic is compounded by its unique abilities to survive in a diverse range of environments, including those within healthcare institutions, leading to problematic outbreaks. Historically, the virulence of the organism has been questioned, but recent clinical reports suggest that Acinetobacter can cause serious, life-threatening infections. Furthermore, its metabolic adaptability gives it a selective advantage in harsh hospital environments. This review focuses on current understanding of A. baumannii pathogenesis and the model systems used to study this interesting organism.
Original languageEnglish
Pages (from-to)1055 - 1060
Number of pages6
JournalIUBMB Life
Volume63
Issue number12
DOIs
Publication statusPublished - 2011

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