Insights and controversies into the role of the key apicomplexan invasion ligand, Apical Membrane Antigen 1

Katherine L Harvey, Alan Yap, Paul R Gilson, Alan Frederick Cowman, Brendan S Crabb

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Abstract

Apicomplexan parasites are obligate intracellular pathogens that cause a host of human and animal diseases. These parasites have developed a universal mechanism of invasion involving formation of a moving junction that provides a stable anchoring point through which the parasite invades host cells. The composition of the moving junction, particularly the presence of the protein Apical Membrane Antigen 1 (AMA1), has recently been the subject of some controversy. In this commentary we review findings that led to the current model of the moving junction complex and dissect the major conflicts to determine whether a substantial reassessment of the role of AMA1 is justified.
Original languageEnglish
Pages (from-to)853 - 857
Number of pages5
JournalInternational Journal for Parasitology
Volume44
Issue number12
DOIs
Publication statusPublished - 2014

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