TY - JOUR
T1 - Insight into synergetic effects of serum albumin and glucose on the biodegradation behavior of WE43 alloy in simulated body fluid
AU - Imani, Amin
AU - Clifford, Amanda M.
AU - Raman, R. K.Singh
AU - Asselin, Edouard
N1 - Funding Information:
The authors gratefully acknowledge funding support from the Natural Sciences and Engineering Research Council (NSERC) of Canada. Amin Imani is financially supported by UBC’s Four-Year Fellowship program.
Publisher Copyright:
© 2022 The Author(s). Published by IOP Publishing Ltd.
PY - 2023/1/1
Y1 - 2023/1/1
N2 - The biodegradation rate of Mg alloy medical devices, such as screws and plates for temporary bone fracture fixation or coronary angioplasty stents, is an increasingly important area of study. In vitro models of the corrosion behavior of these devices use revised simulated body fluid (m-SBF) based on a healthy individual’s blood chemistry. Therefore, model outputs have limited application to patients with altered blood plasma glucose or protein concentrations. This work studies the biodegradation behavior of Mg alloy WE43 in m-SBF modified with varying concentrations of glucose and bovine serum albumin (BSA) to (1) mimic a range of disease states and (2) determine the contributions of each biomolecule to corrosion. Measurements include the Mg ion release rate, electrolyte pH, the extent of hydrogen evolution (as a proxy for corrosion rate), surface morphology, and corrosion product composition and effects. BSA (0.1 g l-1) suppresses the rate of hydrogen evolution (about 30%) after 24 h and—to a lesser degree—Mg2+ release in both the presence and absence of glucose. This effect gets more pronounced with time, possibly due to BSA adsorption on the Mg surface. Electrochemical studies confirm that adding glucose (2 g l-1) to the solution containing BSA (0.1 g l-1) caused a decrease in corrosion resistance (by around 40%), and concomitant increase in the hydrogen evolution rate (from 10.32 to 11.04 mg cm-2 d-1) to levels far beyond the tolerance limits of live tissues.
AB - The biodegradation rate of Mg alloy medical devices, such as screws and plates for temporary bone fracture fixation or coronary angioplasty stents, is an increasingly important area of study. In vitro models of the corrosion behavior of these devices use revised simulated body fluid (m-SBF) based on a healthy individual’s blood chemistry. Therefore, model outputs have limited application to patients with altered blood plasma glucose or protein concentrations. This work studies the biodegradation behavior of Mg alloy WE43 in m-SBF modified with varying concentrations of glucose and bovine serum albumin (BSA) to (1) mimic a range of disease states and (2) determine the contributions of each biomolecule to corrosion. Measurements include the Mg ion release rate, electrolyte pH, the extent of hydrogen evolution (as a proxy for corrosion rate), surface morphology, and corrosion product composition and effects. BSA (0.1 g l-1) suppresses the rate of hydrogen evolution (about 30%) after 24 h and—to a lesser degree—Mg2+ release in both the presence and absence of glucose. This effect gets more pronounced with time, possibly due to BSA adsorption on the Mg surface. Electrochemical studies confirm that adding glucose (2 g l-1) to the solution containing BSA (0.1 g l-1) caused a decrease in corrosion resistance (by around 40%), and concomitant increase in the hydrogen evolution rate (from 10.32 to 11.04 mg cm-2 d-1) to levels far beyond the tolerance limits of live tissues.
KW - bovine serum albumin
KW - corrosion
KW - glucose
KW - Mg-WE43 alloy
KW - simulated body fluid
UR - http://www.scopus.com/inward/record.url?scp=85143379683&partnerID=8YFLogxK
U2 - 10.1088/1748-605X/aca3e8
DO - 10.1088/1748-605X/aca3e8
M3 - Article
C2 - 36395511
AN - SCOPUS:85143379683
SN - 1748-6041
VL - 18
JO - Biomedical Materials
JF - Biomedical Materials
IS - 1
M1 - 015011
ER -