Inositol polyphosphate 5-phosphatases: Lipid phosphatases with flair

Christina A. Mitchell; Rajendra Gurung; Anne M. Kong; Jennifer M. Dyson; April Tan; Lisa M. Ooms

doi:10.1080/15216540210815

Inositol polyphosphate 5-phosphatases: Lipid phosphatases with flair

Christina A. Mitchell, Rajendra Gurung, Anne M. Kong, Jennifer M. Dyson, April Tan, Lisa M. Ooms

Biochemistry & Molecular Biology

Research output: Contribution to journal › Review Article › Research › peer-review

46 Citations (Scopus)

Abstract

Recent studies have identified the inositol polyphosphate 5-phosphatases as a large family of signal modifying enzymes comprising 10 mammalian and 4 yeast family members. A number of investigations including gene-targeted deletion of 5-phosphatases in mice have demonstrated that these enzymes regulate many important cellular events including hematopoietic cell proliferation and activation, insulin signaling, endocytosis, and actin polymerization.

Original language	English
Pages (from-to)	25-36
Number of pages	12
Journal	IUBMB Life
Volume	53
Issue number	1
DOIs	https://doi.org/10.1080/15216540210815
Publication status	Published - 13 May 2002

Keywords

Actin cytoskeleton
B cell proliferation
Calcium signaling
Inositol 5-phosphatase
Insulin signaling
Vesicle trafficking

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10.1080/15216540210815

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abstract = "Recent studies have identified the inositol polyphosphate 5-phosphatases as a large family of signal modifying enzymes comprising 10 mammalian and 4 yeast family members. A number of investigations including gene-targeted deletion of 5-phosphatases in mice have demonstrated that these enzymes regulate many important cellular events including hematopoietic cell proliferation and activation, insulin signaling, endocytosis, and actin polymerization.",

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AU - Kong, Anne M.

AU - Dyson, Jennifer M.

AU - Tan, April

AU - Ooms, Lisa M.

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KW - B cell proliferation

KW - Calcium signaling

KW - Inositol 5-phosphatase

KW - Insulin signaling

KW - Vesicle trafficking

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Inositol polyphosphate 5-phosphatases: Lipid phosphatases with flair

Abstract

Keywords

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