Inositol polyphosphate 5-phosphatases: Lipid phosphatases with flair

Christina A. Mitchell, Rajendra Gurung, Anne M. Kong, Jennifer M. Dyson, April Tan, Lisa M. Ooms

Research output: Contribution to journalReview ArticleResearchpeer-review

46 Citations (Scopus)


Recent studies have identified the inositol polyphosphate 5-phosphatases as a large family of signal modifying enzymes comprising 10 mammalian and 4 yeast family members. A number of investigations including gene-targeted deletion of 5-phosphatases in mice have demonstrated that these enzymes regulate many important cellular events including hematopoietic cell proliferation and activation, insulin signaling, endocytosis, and actin polymerization.

Original languageEnglish
Pages (from-to)25-36
Number of pages12
JournalIUBMB Life
Issue number1
Publication statusPublished - 13 May 2002


  • Actin cytoskeleton
  • B cell proliferation
  • Calcium signaling
  • Inositol 5-phosphatase
  • Insulin signaling
  • Vesicle trafficking

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