Innate Lymphoid Cells Type 3

Gabrielle T. Belz, Lucille C. Rankin, Sebastian Carotta, Chiara Romagnani, Nicholas D. Huntington

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review


Retinoic acid receptor-related (RAR) orphan receptor γ (Rorγt+) innate lymphoid cells or group 3 innate lymphoid cells (ILC3s) play key roles in the development of lymphoid tissues, maintenance of epithelial tissue homeostasis, and repair and defense against pathogens encountered at the body's barriers. These cells produce interleukin (IL)-22, IL-17A, and lymphotoxin (LT)α1β2 which are critical cytokines necessary for induction of the protective pathways at epithelial and mucosal surfaces. The ILC3 are a heterogeneous group of cells. Significant efforts have been made to decipher the transcriptional program that regulates their development and to understand the functions and mechanisms of actions of the individual subsets in providing immune protection.

Original languageEnglish
Title of host publicationEncyclopedia of Immunobiology
Number of pages13
ISBN (Print)9780080921525
Publication statusPublished - 27 Apr 2016
Externally publishedYes


  • Adaptive immunity
  • Cytokines
  • Development
  • Gastrointestinal tract
  • Gut
  • Immune protection
  • Innate immunity
  • Innate lymphoid cells
  • Innate protection
  • Lung
  • Mucosal tissues
  • Tolerance

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