Innate Lymphoid Cells Type 3

Gabrielle T. Belz; Lucille C. Rankin; Sebastian Carotta; Chiara Romagnani; Nicholas D. Huntington

doi:10.1016/B978-0-12-374279-7.04004-2

Innate Lymphoid Cells Type 3

Gabrielle T. Belz, Lucille C. Rankin, Sebastian Carotta, Chiara Romagnani, Nicholas D. Huntington

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review

Abstract

Retinoic acid receptor-related (RAR) orphan receptor γ (Rorγt⁺) innate lymphoid cells or group 3 innate lymphoid cells (ILC3s) play key roles in the development of lymphoid tissues, maintenance of epithelial tissue homeostasis, and repair and defense against pathogens encountered at the body's barriers. These cells produce interleukin (IL)-22, IL-17A, and lymphotoxin (LT)α₁β₂ which are critical cytokines necessary for induction of the protective pathways at epithelial and mucosal surfaces. The ILC3 are a heterogeneous group of cells. Significant efforts have been made to decipher the transcriptional program that regulates their development and to understand the functions and mechanisms of actions of the individual subsets in providing immune protection.

Original language	English
Title of host publication	Encyclopedia of Immunobiology
Publisher	Elsevier
Pages	156-168
Number of pages	13
Volume	1
ISBN (Print)	9780080921525
DOIs	https://doi.org/10.1016/B978-0-12-374279-7.04004-2
Publication status	Published - 27 Apr 2016
Externally published	Yes

Keywords

Adaptive immunity
Cytokines
Development
Gastrointestinal tract
Gut
Immune protection
Innate immunity
Innate lymphoid cells
Innate protection
Lung
Mucosal tissues
Tolerance

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10.1016/B978-0-12-374279-7.04004-2

Cite this

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title = "Innate Lymphoid Cells Type 3",

abstract = "Retinoic acid receptor-related (RAR) orphan receptor γ (Rorγt+) innate lymphoid cells or group 3 innate lymphoid cells (ILC3s) play key roles in the development of lymphoid tissues, maintenance of epithelial tissue homeostasis, and repair and defense against pathogens encountered at the body's barriers. These cells produce interleukin (IL)-22, IL-17A, and lymphotoxin (LT)α1β2 which are critical cytokines necessary for induction of the protective pathways at epithelial and mucosal surfaces. The ILC3 are a heterogeneous group of cells. Significant efforts have been made to decipher the transcriptional program that regulates their development and to understand the functions and mechanisms of actions of the individual subsets in providing immune protection.",

keywords = "Adaptive immunity, Cytokines, Development, Gastrointestinal tract, Gut, Immune protection, Innate immunity, Innate lymphoid cells, Innate protection, Lung, Mucosal tissues, Tolerance",

author = "Belz, {Gabrielle T.} and Rankin, {Lucille C.} and Sebastian Carotta and Chiara Romagnani and Huntington, {Nicholas D.}",

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AU - Belz, Gabrielle T.

AU - Rankin, Lucille C.

AU - Carotta, Sebastian

AU - Romagnani, Chiara

AU - Huntington, Nicholas D.

PY - 2016/4/27

Y1 - 2016/4/27

N2 - Retinoic acid receptor-related (RAR) orphan receptor γ (Rorγt+) innate lymphoid cells or group 3 innate lymphoid cells (ILC3s) play key roles in the development of lymphoid tissues, maintenance of epithelial tissue homeostasis, and repair and defense against pathogens encountered at the body's barriers. These cells produce interleukin (IL)-22, IL-17A, and lymphotoxin (LT)α1β2 which are critical cytokines necessary for induction of the protective pathways at epithelial and mucosal surfaces. The ILC3 are a heterogeneous group of cells. Significant efforts have been made to decipher the transcriptional program that regulates their development and to understand the functions and mechanisms of actions of the individual subsets in providing immune protection.

AB - Retinoic acid receptor-related (RAR) orphan receptor γ (Rorγt+) innate lymphoid cells or group 3 innate lymphoid cells (ILC3s) play key roles in the development of lymphoid tissues, maintenance of epithelial tissue homeostasis, and repair and defense against pathogens encountered at the body's barriers. These cells produce interleukin (IL)-22, IL-17A, and lymphotoxin (LT)α1β2 which are critical cytokines necessary for induction of the protective pathways at epithelial and mucosal surfaces. The ILC3 are a heterogeneous group of cells. Significant efforts have been made to decipher the transcriptional program that regulates their development and to understand the functions and mechanisms of actions of the individual subsets in providing immune protection.

KW - Adaptive immunity

KW - Cytokines

KW - Development

KW - Gastrointestinal tract

KW - Gut

KW - Immune protection

KW - Innate immunity

KW - Innate lymphoid cells

KW - Innate protection

KW - Lung

KW - Mucosal tissues

KW - Tolerance

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AN - SCOPUS:85043296464

SN - 9780080921525

VL - 1

SP - 156

EP - 168

BT - Encyclopedia of Immunobiology

PB - Elsevier

ER -

Innate Lymphoid Cells Type 3

Abstract

Keywords

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