Innate lymphoid cells: Parallel checkpoints and coordinate interactions with T cells

Nicholas D. Huntington, Sabrina Carpentier, Eric Vivier, Gabrielle T. Belz

Research output: Contribution to journalReview ArticleResearchpeer-review

18 Citations (Scopus)

Abstract

Protection of epithelial and mucosal surfaces is required for survival. The recent discovery of a diverse array of innate lymphoid cells that lie immediately beneath these surfaces has unexpectedly uncovered an entire defense system distinct from the adaptive system essential to protect these barriers. This multilayered design provides a robust system through coupling of two highly complementary networks to ensure immune protection. Here, we discuss the similarities in the hardwiring and diversification of innate lymphoid cells and T cells during mammalian immune responses.

Original languageEnglish
Pages (from-to)86-93
Number of pages8
JournalCurrent Opinion in Immunology
Volume38
DOIs
Publication statusPublished - 1 Feb 2016
Externally publishedYes

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