Innate Immunity in the Central Nervous System

A Missing Piece of the Autoimmune Encephalitis Puzzle?

Robb Wesselingh, Helmut Butzkueven, Katherine Buzzard, David Tarlinton, Terence J. O'Brien, Mastura Monif

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

The autoimmune encephalitides are a group of autoimmune conditions targeting the central nervous system and causing severe clinical symptoms including drug-resistant seizures, cognitive dysfunction and psychiatric disturbance. Although these disorders appear to be antibody mediated, the role of innate immune responses needs further clarification. Infiltrating monocytes and microglial proliferation at the site of pathology could contribute to the pathogenesis of the disease with resultant blood brain barrier dysfunction, and subsequent activation of adaptive immune response. Both innate and adaptive immune cells can produce pro-inflammatory molecules which can perpetuate ongoing neuroinflammation and drive ongoing seizure activity. Ultimately neurodegenerative changes can ensue with resultant long-term neurological sequelae that can impact on ongoing patient morbidity and quality of life, providing a potential target for future translational research.

Original languageEnglish
Article number2066
Number of pages14
JournalFrontiers in Immunology
Volume10
DOIs
Publication statusPublished - 1 Jan 2019

Keywords

  • autoimmune encephalitis
  • blood brain barrier
  • epilepsy
  • innate immunity
  • microglia
  • monocytes
  • neuroimmunology

Cite this

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title = "Innate Immunity in the Central Nervous System: A Missing Piece of the Autoimmune Encephalitis Puzzle?",
abstract = "The autoimmune encephalitides are a group of autoimmune conditions targeting the central nervous system and causing severe clinical symptoms including drug-resistant seizures, cognitive dysfunction and psychiatric disturbance. Although these disorders appear to be antibody mediated, the role of innate immune responses needs further clarification. Infiltrating monocytes and microglial proliferation at the site of pathology could contribute to the pathogenesis of the disease with resultant blood brain barrier dysfunction, and subsequent activation of adaptive immune response. Both innate and adaptive immune cells can produce pro-inflammatory molecules which can perpetuate ongoing neuroinflammation and drive ongoing seizure activity. Ultimately neurodegenerative changes can ensue with resultant long-term neurological sequelae that can impact on ongoing patient morbidity and quality of life, providing a potential target for future translational research.",
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Innate Immunity in the Central Nervous System : A Missing Piece of the Autoimmune Encephalitis Puzzle? / Wesselingh, Robb; Butzkueven, Helmut; Buzzard, Katherine; Tarlinton, David; O'Brien, Terence J.; Monif, Mastura.

In: Frontiers in Immunology, Vol. 10, 2066, 01.01.2019.

Research output: Contribution to journalReview ArticleResearchpeer-review

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AU - O'Brien, Terence J.

AU - Monif, Mastura

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AB - The autoimmune encephalitides are a group of autoimmune conditions targeting the central nervous system and causing severe clinical symptoms including drug-resistant seizures, cognitive dysfunction and psychiatric disturbance. Although these disorders appear to be antibody mediated, the role of innate immune responses needs further clarification. Infiltrating monocytes and microglial proliferation at the site of pathology could contribute to the pathogenesis of the disease with resultant blood brain barrier dysfunction, and subsequent activation of adaptive immune response. Both innate and adaptive immune cells can produce pro-inflammatory molecules which can perpetuate ongoing neuroinflammation and drive ongoing seizure activity. Ultimately neurodegenerative changes can ensue with resultant long-term neurological sequelae that can impact on ongoing patient morbidity and quality of life, providing a potential target for future translational research.

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