Innate immunity defines the capacity of antiviral T cells to limit persistent infection

Daniel M. Andrews, Marie J. Estcourt, Christopher E Andoniou, Matthew E Wikstrom, Andrea Khong, Valentina Voigt, Peter Fleming, Hyacinth Tabarias, Geoffrey R Hill, Robbert G. Van Der Most, Anthony Scalzo, Mark J. Smyth, Mariapia A Degli-Esposti

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168 Citations (Scopus)


Effective immunity requires the coordinated activation of innate and adaptive immune responses. Natural killer (NK) cells are central innate immune effectors, but can also affect the generation of acquired immune responses to viruses and malignancies. How NK cells influence the efficacy of adaptive immunity, however, is poorly understood. Here, we show that NK cells negatively regulate the duration and effectiveness of virus-specific CD4+ and CD8+ T cell responses by limiting exposure of T cells to infected antigen-presenting cells. This impacts the quality of T cell responses and the ability to limit viral persistence. Our studies provide unexpected insights into novel interplays between innate and adaptive immune effectors, and define the critical requirements for efficient control of viral persistence.

Original languageEnglish
Pages (from-to)1333-1343
Number of pages11
JournalJournal of Experimental Medicine
Issue number6
Publication statusPublished - 7 Jun 2010

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