Innate immunity: cytoplasmic DNA sensing by the AIM2 inflammasome

Kate Schroder, Daniel A Muruve, Jurg Tschopp

Research output: Contribution to journalArticleResearchpeer-review

98 Citations (Scopus)

Abstract

Cytoplasmic double-stranded DNA triggers cell death and secretion of the pro-inflammatory cytokine interleukin-1beta in macrophages. Recent reports now describe the mechanism underlying this observation. Upon sensing of DNA, the HIN-200 family member AIM2 triggers the assembly of the inflammasome, culminating in caspase-1 activation, interleukin-1beta maturation and pyroptotic cell death.
Original languageEnglish
Pages (from-to)R262 - R265
Number of pages4
JournalCurrent Biology
Volume19
Issue number6
Publication statusPublished - 2009

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