Cytoplasmic double-stranded DNA triggers cell death and secretion of the pro-inflammatory cytokine interleukin-1beta in macrophages. Recent reports now describe the mechanism underlying this observation. Upon sensing of DNA, the HIN-200 family member AIM2 triggers the assembly of the inflammasome, culminating in caspase-1 activation, interleukin-1beta maturation and pyroptotic cell death.
|Pages (from-to)||R262 - R265|
|Number of pages||4|
|Publication status||Published - 2009|