Natürliche und adaptive immunität des respirationstraktes - Bedeutung mikrobieller faktoren für infektabwehr und sensibilisierung - Teil III

Translated title of the contribution: Innate and adaptive immunity of the respiratory tract - The role of microbial factors for host defense and sensitization - Part III

W. König, H. Lauf, U. Arnold, I. Tammer, B. Ghebremedhin, A. Clarici, F. L. Thies, A. Drynda, A. Schmalcz, T. Kwok, R. Arnold, S. Backert, H. Werchau, B. König

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

It is clear by now, that a simple scheme, how allergy within the respiratory tract occurs, can no further been drawn. However, despite the complex interaction, key modules within the inflammatory responses and the recognition of exogenous ligands have been delineated. These imply the uptake of allergens, the recognition of their epitopes, their structural similarities and cross-reactivities, the maturation of dendritic cells as well as the expression of cellular epitopes and adhesion molecules in relation to various effector functions. Inflammation as an initial result during allergic sensitization combines all these effects and finally leads within the adaptive immune response to the events which result in impaired functions and deleterious effects in the long-lasting allergy march. From these basic experiences which have been drawn from the past 20 years, it became clear that within the various modules of innate as well as adaptive immune responses which are responsible for acute and chronic inflammation novel strategic points can be outlined for future therapeutic strategies. Thus, the "umbrella" of mechanisms under which allergy, asthma, atopic dermatitis are combined, became more complex but, on the other hand, more precise for the potential intervention of inflammation per se. This, however, can not be carried out by one scientific discipline alone. Interdisciplinary approaches are necessary and comprise the efforts of clinicians, basic clinical research as well as basic research. One scientific field will not be able to pursue sufficient answers and to develop novel avenues in the treatment of allergy and inflammation. The past 25 years clearly demonstrated that the less we work together the poorer will be our views, the more and closer we work, the wider will be the joy of efficacy and efficient intervention in combating diseases. The present manuscript is, therefore, a plea for interdisciplinary and innovative interactions and it has to be clearly stated that allergy is certainly not the field for the clinician alone but the field in basic medicine as well.

Original languageGerman
Pages (from-to)188-203
Number of pages16
JournalAtemwegs- und Lungenkrankheiten
Volume31
Issue number4
Publication statusPublished - Apr 2005
Externally publishedYes

Keywords

  • Asthma
  • Atopic dermatitis
  • Chemokines
  • Cytokines
  • Defensins
  • Eosinophils
  • Epithelial cells
  • Histamine
  • Innate and adaptive immunity
  • Leukotrienes
  • Mast cells
  • TH1/TH2 dichotomy
  • Tissue remodelling
  • Toll-Like receptors
  • Tt-regulatory cells

Cite this

König, W., Lauf, H., Arnold, U., Tammer, I., Ghebremedhin, B., Clarici, A., Thies, F. L., Drynda, A., Schmalcz, A., Kwok, T., Arnold, R., Backert, S., Werchau, H., & König, B. (2005). Natürliche und adaptive immunität des respirationstraktes - Bedeutung mikrobieller faktoren für infektabwehr und sensibilisierung - Teil III. Atemwegs- und Lungenkrankheiten, 31(4), 188-203.