Injury and inflammation from resuscitation of the preterm infant

Alan H. Jobe, Noah Hillman, Graeme Polglase, Boris W. Kramer, Suhas Kallapur, Jane J. Pillow

Research output: Contribution to journalReview ArticleResearchpeer-review

123 Citations (Scopus)

Abstract

We review information about how the preterm lung can be injured with the initiation of mechanical ventilation at birth. Although multiple variables such as pressure, tidal volume, positive end expiratory pressure, and the gas used for ventilation may contribute to the injury, the relative contribution of each is not known. Recent studies demonstrate that injury caused by initial high tidal volume is amplified by subsequent mechanical ventilation. A model for gas inflation of the fluid-filled lung may explain why even low tidal volumes may injure the preterm lung, and why the injury may initially occur to the small airways. Ventilation strategies that minimize injury need to be developed.

Original languageEnglish
Pages (from-to)190-196
Number of pages7
JournalNeonatology
Volume94
Issue number3
DOIs
Publication statusPublished - 1 Oct 2008
Externally publishedYes

Keywords

  • Bronchopulmonary dysplasia
  • Cytokines
  • Lung injury
  • Mechanical ventilation

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