Initial SYNTAX score predicts major adverse cardiac events after primary percutaneous coronary intervention

Adam J. Brown, Liam M. McCormick, Parag R. Gajendragadkar, Stephen P. Hoole, Nick E.J. West

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)


We assessed whether interventional complexity in patients presenting with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI) predicted long-term outcome. Consecutive patients undergoing PPCI for STEMI underwent SYNTAX scoring, based on angiographic images obtained at coronary intervention. Patients were classified as SYNTAX score (SS) ≥22 (low, L), 23 to 32 [intermediate (IM)], and ≥33 (high, H). The median SS for the cohort was 19 [Interquartile range (IQR), 11.0-25.5] with median tertile scores of L 14 (IQR 9.0-18.5, n = 437), IM 26 (IQR 24.0-28.5, n = 170), and H 36 (IQR 34.5-40.5, n = 67). Two-year freedom from major adverse cardiac events (MACE) was L 88.1%, IM 78.8%, and H 68.7% (P <.001). Multivariate analysis confirmed that increasing SS tertile was an independent predictor of MACE [IM hazard ratio (HR) 1.61, confidence interval (CI) 1.05-2.47; P =.03, H HR 1.99, CI 1.16-3.41; P =.01]. The SS, when applied to patients undergoing PPCI for STEMI, provides prognostic information.

Original languageEnglish
Pages (from-to)408-412
Number of pages5
Issue number5
Publication statusPublished - 1 May 2014
Externally publishedYes


  • primary percutaneous coronary intervention
  • ST-segment elevation myocardial infarction
  • SYNTAX score

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