TY - JOUR
T1 - Initial SYNTAX score predicts major adverse cardiac events after primary percutaneous coronary intervention
AU - Brown, Adam J.
AU - McCormick, Liam M.
AU - Gajendragadkar, Parag R.
AU - Hoole, Stephen P.
AU - West, Nick E.J.
PY - 2014/5/1
Y1 - 2014/5/1
N2 - We assessed whether interventional complexity in patients presenting with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI) predicted long-term outcome. Consecutive patients undergoing PPCI for STEMI underwent SYNTAX scoring, based on angiographic images obtained at coronary intervention. Patients were classified as SYNTAX score (SS) ≥22 (low, L), 23 to 32 [intermediate (IM)], and ≥33 (high, H). The median SS for the cohort was 19 [Interquartile range (IQR), 11.0-25.5] with median tertile scores of L 14 (IQR 9.0-18.5, n = 437), IM 26 (IQR 24.0-28.5, n = 170), and H 36 (IQR 34.5-40.5, n = 67). Two-year freedom from major adverse cardiac events (MACE) was L 88.1%, IM 78.8%, and H 68.7% (P <.001). Multivariate analysis confirmed that increasing SS tertile was an independent predictor of MACE [IM hazard ratio (HR) 1.61, confidence interval (CI) 1.05-2.47; P =.03, H HR 1.99, CI 1.16-3.41; P =.01]. The SS, when applied to patients undergoing PPCI for STEMI, provides prognostic information.
AB - We assessed whether interventional complexity in patients presenting with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI) predicted long-term outcome. Consecutive patients undergoing PPCI for STEMI underwent SYNTAX scoring, based on angiographic images obtained at coronary intervention. Patients were classified as SYNTAX score (SS) ≥22 (low, L), 23 to 32 [intermediate (IM)], and ≥33 (high, H). The median SS for the cohort was 19 [Interquartile range (IQR), 11.0-25.5] with median tertile scores of L 14 (IQR 9.0-18.5, n = 437), IM 26 (IQR 24.0-28.5, n = 170), and H 36 (IQR 34.5-40.5, n = 67). Two-year freedom from major adverse cardiac events (MACE) was L 88.1%, IM 78.8%, and H 68.7% (P <.001). Multivariate analysis confirmed that increasing SS tertile was an independent predictor of MACE [IM hazard ratio (HR) 1.61, confidence interval (CI) 1.05-2.47; P =.03, H HR 1.99, CI 1.16-3.41; P =.01]. The SS, when applied to patients undergoing PPCI for STEMI, provides prognostic information.
KW - primary percutaneous coronary intervention
KW - ST-segment elevation myocardial infarction
KW - SYNTAX score
UR - http://www.scopus.com/inward/record.url?scp=84898934695&partnerID=8YFLogxK
U2 - 10.1177/0003319713483542
DO - 10.1177/0003319713483542
M3 - Article
C2 - 23574751
AN - SCOPUS:84898934695
SN - 0003-3197
VL - 65
SP - 408
EP - 412
JO - Angiology
JF - Angiology
IS - 5
ER -