Initial modelling and updates on cost effectiveness from the first 10 years of a spleen registry

Sarah Luu, Penelope Jones, Ian Woolley, Denis Spelman, Lisa Gold

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)


Objective: To validate our estimates from our original model and re-evaluate the cost-effectiveness of Spleen Australia, the Australian post-splenectomy registry, using our original model with updated model parameters based on advances in the literature and experience of the registry over the past decade. Methods: We revisited a decision model from 2005, comparing 1,000 hypothetical registered patients with asplenia or hyposplenism against 1,000 who were not registered, and updated the model parameters. The cost-effectiveness of the registry was evaluated from a healthcare perspective in terms of additional cost per case of overwhelming post-splenectomy infection (OPSI) avoided and as additional cost per life year gained. Results: Over a cohort lifetime the registry was associated with an additional cost of $125,724 per case of OPSI avoided or $19,286 per life year gained. Conclusions: Despite our initial over-estimation of immunisation and chemoprophylaxis uptake and increases in unit costs, our re-evaluation confirmed use of the registry to be cost-effective. Implications for public health: Improved outcomes for patients with asplenia or hyposplenism can be achieved by a cost-effective registry. Additional research into effectiveness of interventions, OPSI prevalence associated with varying intervention use, and compliance rates over time after registration would provide improved accuracy of cost-effectiveness estimates.

Original languageEnglish
Pages (from-to)463-466
Number of pages4
JournalAustralian and New Zealand Journal of Public Health
Issue number5
Publication statusPublished - 1 Oct 2018


  • cost-effectiveness
  • registry
  • spleen

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