TY - JOUR
T1 - Inhibitory potential of resveratrol in cancer metastasis
T2 - from biology to therapy
AU - Song, Baohong
AU - Wang, Wei
AU - Tang, Xuemei
AU - Goh, Robby Miguel Wen Jing
AU - Thuya, Win Lwin
AU - Ho, Paul Chi Lui
AU - Chen, Lu
AU - Wang, Lingzhi
N1 - Funding Information:
This research was financially supported by the Fund of Project of Inheritance Studio of National Famous Experts of State Administration of TCM (no. [2019] 41, L.C.), the First Batch of Key Projects of TCM Discipline Construction in Sichuan Province: Pharmaceutical Botany (no. [2020] 84, L.C.), “XingLin Scholars” Research Promotion Plan of Chengdu University of TCM (no. QJRC2022017, L.C.). This research is also supported by the National Research Foundation Singapore and the Singapore Ministry of Education under its Research Centers of Excellence initiative and the Singapore Ministry of Health’s National Medical Research Council (NMRC/CNIG/1146/2016, L.W.).
Publisher Copyright:
© 2023 by the authors.
PY - 2023/5
Y1 - 2023/5
N2 - Cancer metastasis is a significant challenge in cancer treatment, and most existing drugs are designed to inhibit tumor growth but are often ineffective in treating metastatic cancer, which is the leading cause of cancer-related deaths. Resveratrol, a polyphenol found in grapes, berries, and peanuts, has shown potential in preclinical studies as an anticancer agent to suppress metastasis. However, despite positive results in preclinical studies, little progress has been made in clinical trials. To develop resveratrol as an effective anticancer agent, it is crucial to understand its cellular processes and signaling pathways in tumor metastasis. This review article evaluates the current state and future development strategies of resveratrol to enhance its potency against cancer metastasis within its therapeutic dose. In addition, we critically evaluate the animal models used in preclinical studies for cancer metastasis and discuss novel techniques to accelerate the translation of resveratrol from bench to bedside. The appropriate selection of animal models is vital in determining whether resveratrol can be further developed as an antimetastatic drug in cancer therapy.
AB - Cancer metastasis is a significant challenge in cancer treatment, and most existing drugs are designed to inhibit tumor growth but are often ineffective in treating metastatic cancer, which is the leading cause of cancer-related deaths. Resveratrol, a polyphenol found in grapes, berries, and peanuts, has shown potential in preclinical studies as an anticancer agent to suppress metastasis. However, despite positive results in preclinical studies, little progress has been made in clinical trials. To develop resveratrol as an effective anticancer agent, it is crucial to understand its cellular processes and signaling pathways in tumor metastasis. This review article evaluates the current state and future development strategies of resveratrol to enhance its potency against cancer metastasis within its therapeutic dose. In addition, we critically evaluate the animal models used in preclinical studies for cancer metastasis and discuss novel techniques to accelerate the translation of resveratrol from bench to bedside. The appropriate selection of animal models is vital in determining whether resveratrol can be further developed as an antimetastatic drug in cancer therapy.
KW - cancer therapy
KW - metastasis animal model
KW - resveratrol
KW - tumor metastasis
UR - http://www.scopus.com/inward/record.url?scp=85160639131&partnerID=8YFLogxK
U2 - 10.3390/cancers15102758
DO - 10.3390/cancers15102758
M3 - Review Article
AN - SCOPUS:85160639131
SN - 2072-6694
VL - 15
JO - Cancers
JF - Cancers
IS - 10
M1 - 2758
ER -
