Inhibitory activities of microalgal extracts against Epstein-Barr virus (EBV) antigen expression in lymphoblastoid cells

Yih Yih Kok, Wan Loy Chu, Siew Moi Phang, Shar Mariam Mohamed, Rakesh Naidu, Pey Jiun Lai, Shui Nyuk Ling, Joon Wah Mak, Patricia Kim Chooi Lim, Pauline Balraj, Alan Soo Beng Khoo

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    Abstract

    The inhibitory activities of microalgal extracts against the expression of three EBV antigens, latent membrane protein (LMP)1, Epstein-Barr nuclear antigen (EBNA)1 and Z Epstein-Barr reactivation activator (ZEBRA) were assessed by immunocytochemistry. The observation that the methanol extracts and their fractions from Ankistrodesmus convolutus, Synechococcus elongatus and Spirulina platensis exhibited inhibitory activity against EBV proteins in three Burkitt s lymphoma cell lines at concentrations as low as 20 ?g/ml suggests that microalgae could be a potential source of antiviral compounds against EBV.
    Original languageEnglish
    Pages (from-to)1009 - 1024
    Number of pages16
    JournalArchives of Biological Sciences
    Volume66
    Issue number3
    DOIs
    Publication statusPublished - 2014

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