Inhibitory activities of microalgal extracts against Epstein-Barr virus (EBV) antigen expression in lymphoblastoid cells

Yih Yih Kok; Wan Loy Chu; Siew Moi Phang; Shar Mariam Mohamed; Rakesh Naidu; Pey Jiun Lai; Shui Nyuk Ling; Joon Wah Mak; Patricia Kim Chooi Lim; Pauline Balraj; Alan Soo Beng Khoo

doi:10.2298/ABS1403009K

Inhibitory activities of microalgal extracts against Epstein-Barr virus (EBV) antigen expression in lymphoblastoid cells

Yih Yih Kok, Wan Loy Chu, Siew Moi Phang, Shar Mariam Mohamed, Rakesh Naidu, Pey Jiun Lai, Shui Nyuk Ling, Joon Wah Mak, Patricia Kim Chooi Lim, Pauline Balraj, Alan Soo Beng Khoo

Malaysia Jeffrey Cheah Sch of Med & HS

Research output: Contribution to journal › Article › Research › peer-review

1 Citation (Scopus)

Abstract

The inhibitory activities of microalgal extracts against the expression of three EBV antigens, latent membrane protein (LMP)1, Epstein-Barr nuclear antigen (EBNA)1 and Z Epstein-Barr reactivation activator (ZEBRA) were assessed by immunocytochemistry. The observation that the methanol extracts and their fractions from Ankistrodesmus convolutus, Synechococcus elongatus and Spirulina platensis exhibited inhibitory activity against EBV proteins in three Burkitt s lymphoma cell lines at concentrations as low as 20 ?g/ml suggests that microalgae could be a potential source of antiviral compounds against EBV.

Original language	English
Pages (from-to)	1009 - 1024
Number of pages	16
Journal	Archives of Biological Sciences
Volume	66
Issue number	3
DOIs	https://doi.org/10.2298/ABS1403009K
Publication status	Published - 2014

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title = "Inhibitory activities of microalgal extracts against Epstein-Barr virus (EBV) antigen expression in lymphoblastoid cells",

abstract = "The inhibitory activities of microalgal extracts against the expression of three EBV antigens, latent membrane protein (LMP)1, Epstein-Barr nuclear antigen (EBNA)1 and Z Epstein-Barr reactivation activator (ZEBRA) were assessed by immunocytochemistry. The observation that the methanol extracts and their fractions from Ankistrodesmus convolutus, Synechococcus elongatus and Spirulina platensis exhibited inhibitory activity against EBV proteins in three Burkitt s lymphoma cell lines at concentrations as low as 20 ?g/ml suggests that microalgae could be a potential source of antiviral compounds against EBV.",

author = "Kok, {Yih Yih} and Chu, {Wan Loy} and Phang, {Siew Moi} and Mohamed, {Shar Mariam} and Rakesh Naidu and Lai, {Pey Jiun} and Ling, {Shui Nyuk} and Mak, {Joon Wah} and Lim, {Patricia Kim Chooi} and Pauline Balraj and Khoo, {Alan Soo Beng}",

year = "2014",

doi = "10.2298/ABS1403009K",

language = "English",

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T1 - Inhibitory activities of microalgal extracts against Epstein-Barr virus (EBV) antigen expression in lymphoblastoid cells

AU - Kok, Yih Yih

AU - Chu, Wan Loy

AU - Phang, Siew Moi

AU - Mohamed, Shar Mariam

AU - Naidu, Rakesh

AU - Lai, Pey Jiun

AU - Ling, Shui Nyuk

AU - Mak, Joon Wah

AU - Lim, Patricia Kim Chooi

AU - Balraj, Pauline

AU - Khoo, Alan Soo Beng

PY - 2014

Y1 - 2014

N2 - The inhibitory activities of microalgal extracts against the expression of three EBV antigens, latent membrane protein (LMP)1, Epstein-Barr nuclear antigen (EBNA)1 and Z Epstein-Barr reactivation activator (ZEBRA) were assessed by immunocytochemistry. The observation that the methanol extracts and their fractions from Ankistrodesmus convolutus, Synechococcus elongatus and Spirulina platensis exhibited inhibitory activity against EBV proteins in three Burkitt s lymphoma cell lines at concentrations as low as 20 ?g/ml suggests that microalgae could be a potential source of antiviral compounds against EBV.

AB - The inhibitory activities of microalgal extracts against the expression of three EBV antigens, latent membrane protein (LMP)1, Epstein-Barr nuclear antigen (EBNA)1 and Z Epstein-Barr reactivation activator (ZEBRA) were assessed by immunocytochemistry. The observation that the methanol extracts and their fractions from Ankistrodesmus convolutus, Synechococcus elongatus and Spirulina platensis exhibited inhibitory activity against EBV proteins in three Burkitt s lymphoma cell lines at concentrations as low as 20 ?g/ml suggests that microalgae could be a potential source of antiviral compounds against EBV.

UR - http://www.doiserbia.nb.rs/img/doi/0354-4664/2014/0354-46641403009K.pdf

U2 - 10.2298/ABS1403009K

DO - 10.2298/ABS1403009K

M3 - Article

SN - 0354-4664

VL - 66

SP - 1009

EP - 1024

JO - Archives of Biological Sciences

JF - Archives of Biological Sciences

IS - 3

ER -

Inhibitory activities of microalgal extracts against Epstein-Barr virus (EBV) antigen expression in lymphoblastoid cells

Abstract

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