Inhibition of the B cell by CD22: A requirement for Lyn

Kenneth G.C. Smith, David M. Tarlinton, Gina M. Doody, Margaret L. Hibbs, Douglas T. Fearon

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Mice in which the Lyn, Cd22, or Shp-1 gene has been disrupted have hyperactive B cells and autoantibodies. We find that in the absence of Lyn, the ability of CD22 to become tyrosine phosphorylated after ligation of mIg, to recruit SHP-1, and to suppress mIg-induced elevation of intracellular [Ca2+] is lost. Therefore, Lyn is required for the SHP-1-mediated B cell suppressive function of CD22, accounting for similarities in the phenotypes of these mice.

Original languageEnglish
Pages (from-to)807-811
Number of pages5
JournalJournal of Experimental Medicine
Issue number5
Publication statusPublished - 2 Mar 1998

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